N-(5-Octyloxy-2-pyridin-3-yl-phenyl)-3-(2,2,2-trifluoro-acetylamino)-butyramide

Base Information

Chemical Name:N-(5-Octyloxy-2-pyridin-3-yl-phenyl)-3-(2,2,2-trifluoro-acetylamino)-butyramide
CAS No.:158461-89-3
Molecular Formula:C₂₅H₃₂F₃N₃O₃
Molecular Weight:479.543
Hs Code.:

Synonyms:N-(5-Octyloxy-2-pyridin-3-yl-phenyl)-3-(2,2,2-trifluoro-acetylamino)-butyramide

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Chemical Property of N-(5-Octyloxy-2-pyridin-3-yl-phenyl)-3-(2,2,2-trifluoro-acetylamino)-butyramide

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Technology Process of N-(5-Octyloxy-2-pyridin-3-yl-phenyl)-3-(2,2,2-trifluoro-acetylamino)-butyramide

There total 7 articles about N-(5-Octyloxy-2-pyridin-3-yl-phenyl)-3-(2,2,2-trifluoro-acetylamino)-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 5-Octyloxy-2-pyridin-3-yl-phenylamine; hydrochloride

: N-TFA-3-aminobutyryl chloride

: 158461-89-3
N-(5-Octyloxy-2-pyridin-3-yl-phenyl)-3-(2,2,2-trifluoro-acetylamino)-butyramide

Guidance literature:: With triethylamine; In tetrahydrofuran; Ambient temperature;
DOI:10.1248/cpb.41.1573

Reference yield:

: 110-86-1
pyridine

: 158461-89-3
N-(5-Octyloxy-2-pyridin-3-yl-phenyl)-3-(2,2,2-trifluoro-acetylamino)-butyramide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) HNO₂

2: 69 percent / 47percent HBr / H₂O / 8 h / 120 °C

3: 100 percent / K₂CO₃, KI / dimethylformamide / 1 h / 70 °C

4: 73 percent / SnCl₂, conc. HCl / ethanol / 2 h / 100 °C

5: 87 percent / Et₃N / tetrahydrofuran / Ambient temperature

With hydrogenchloride; hydrogen bromide; cis-nitrous acid; potassium carbonate; triethylamine; potassium iodide; tin(ll) chloride; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.41.1573

Reference yield:

: 111-83-1
1-bromo-octane

: 158461-89-3
N-(5-Octyloxy-2-pyridin-3-yl-phenyl)-3-(2,2,2-trifluoro-acetylamino)-butyramide

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / K₂CO₃, KI / dimethylformamide / 1 h / 70 °C

2: 73 percent / SnCl₂, conc. HCl / ethanol / 2 h / 100 °C

3: 87 percent / Et₃N / tetrahydrofuran / Ambient temperature

With hydrogenchloride; potassium carbonate; triethylamine; potassium iodide; tin(ll) chloride; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.41.1573