(S)-benzyl 4-((3-(((tert-butoxycarbonyl)amino)(phenyl)methyl)phenoxy)methyl)piperidine-1-carboxylate

Base Information

Chemical Name:(S)-benzyl 4-((3-(((tert-butoxycarbonyl)amino)(phenyl)methyl)phenoxy)methyl)piperidine-1-carboxylate
CAS No.:1613464-93-9
Molecular Formula:C₃₂H₃₈N₂O₅
Molecular Weight:530.664
Hs Code.:

Synonyms:(S)-benzyl 4-((3-(((tert-butoxycarbonyl)amino)(phenyl)methyl)phenoxy)methyl)piperidine-1-carboxylate

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Chemical Property of (S)-benzyl 4-((3-(((tert-butoxycarbonyl)amino)(phenyl)methyl)phenoxy)methyl)piperidine-1-carboxylate

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Technology Process of (S)-benzyl 4-((3-(((tert-butoxycarbonyl)amino)(phenyl)methyl)phenoxy)methyl)piperidine-1-carboxylate

There total 3 articles about (S)-benzyl 4-((3-(((tert-butoxycarbonyl)amino)(phenyl)methyl)phenoxy)methyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 160586-68-5
4-(toluene-4-sulfonyloxymethyl)piperidine-1-carboxylic acid benzyl ester

: 1416070-91-1
(S)-tert-butyl ((3-hydroxyphenyl)(phenyl)methyl)carbamate

: 1613464-93-9
(S)-benzyl 4-((3-(((tert-butoxycarbonyl)amino)(phenyl)methyl)phenoxy)methyl)piperidine-1-carboxylate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 17h;

Reference yield:

: 1416069-62-9
(S)-tert-butyl ((3-hydroxyphenyl)(phenyl)methyl)carbamate

: 1613464-93-9
(S)-benzyl 4-((3-(((tert-butoxycarbonyl)amino)(phenyl)methyl)phenoxy)methyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: CHIRALPAK AD 20 / isopropyl alcohol; n-heptane; diethylamine / 25 °C / Resolution of racemate

2: caesium carbonate / N,N-dimethyl-formamide / 17 h / 50 °C

With caesium carbonate; In n-heptane; diethylamine; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1613464-93-9
(S)-benzyl 4-((3-(((tert-butoxycarbonyl)amino)(phenyl)methyl)phenoxy)methyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 0 - 20 °C

2: CHIRALPAK AD 20 / isopropyl alcohol; n-heptane; diethylamine / 25 °C / Resolution of racemate

3: caesium carbonate / N,N-dimethyl-formamide / 17 h / 50 °C

With caesium carbonate; N-ethyl-N,N-diisopropylamine; In n-heptane; dichloromethane; diethylamine; N,N-dimethyl-formamide; isopropyl alcohol;