4-(Toluene-4-sulfonyloxymethyl)-piperidine-1-carboxylic acid benzyl ester, 98 %

Base Information

• Chemical Name: 4-(Toluene-4-sulfonyloxymethyl)-piperidine-1-carboxylic acid benzyl ester, 98 %
• CAS No.: 160586-68-5
• Molecular Formula: C21H25 N O5 S
• Molecular Weight: 403.499
• Hs Code.: 2933399090
• Mol file: 160586-68-5.mol

Synonyms:4-(Tosyloxymethyl)-N-(carbobenzyloxy)piperidine

Chemical Property of 4-(Toluene-4-sulfonyloxymethyl)-piperidine-1-carboxylic acid benzyl ester, 98 %

Chemical Property:

• Boiling Point: 559.2±33.0 °C(Predicted)
• PKA: -1.99±0.40(Predicted)
• PSA: 81.29000
• Density: 1.238
• LogP: 4.76780

Purity/Quality:

97% ^*data from raw suppliers

4-(Toluene-4-sulfonyloxymethyl)-piperidine-1-carboxylicacidbenzylester 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(Toluene-4-sulfonyloxymethyl)-piperidine-1-carboxylic acid benzyl ester, 98 %

There total 4 articles about 4-(Toluene-4-sulfonyloxymethyl)-piperidine-1-carboxylic acid benzyl ester, 98 % which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

p-toluenesulfonyl chloride (98-59-9) + benzyl 4-(hydroxymethyl)piperidine-N-carboxylate (122860-33-7) → 4-(toluene-4-sulfonyloxymethyl)piperidine-1-carboxylic acid benzyl ester (160586-68-5)

Guidance literature:

With pyridine; at 0 - 20 ℃; for 19.6667h; Inert atmosphere;

Reference yield: 80.0%

→ 4-(toluene-4-sulfonyloxymethyl)piperidine-1-carboxylic acid benzyl ester (160586-68-5)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield:

4-piperidinemethanol (6457-49-4) → 4-(toluene-4-sulfonyloxymethyl)piperidine-1-carboxylic acid benzyl ester (160586-68-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: triethylamine / dichloromethane / 20 °C

With triethylamine; In dichloromethane;

DOI:10.1002/bkcs.12254

upstream raw materials:

p-toluenesulfonyl chloride

benzyl 4-(hydroxymethyl)piperidine-N-carboxylate

4-piperidinemethanol

benzyl chloroformate

Downstream raw materials:

4-(6-fluoro-indol-1-ylmethyl)-piperidine-1-carboxylic acid benzyl ester

4-piperidinemethylfluoride