diethyl 3-amino-2-cyano-4-(3'-phenyl-4'-hydroxythiazol-2-yl)-2-pentene-1,5-dicarboxylate

Base Information

• Chemical Name: diethyl 3-amino-2-cyano-4-(3'-phenyl-4'-hydroxythiazol-2-yl)-2-pentene-1,5-dicarboxylate
• CAS No.: 142168-47-6
• Molecular Formula: C₁₉H₁₉N₃O₅S
• Molecular Weight: 401.443

Synonyms:diethyl 3-amino-2-cyano-4-(3'-phenyl-4'-hydroxythiazol-2-yl)-2-pentene-1,5-dicarboxylate

Chemical Property of diethyl 3-amino-2-cyano-4-(3'-phenyl-4'-hydroxythiazol-2-yl)-2-pentene-1,5-dicarboxylate

Chemical Property:

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Technology Process of diethyl 3-amino-2-cyano-4-(3'-phenyl-4'-hydroxythiazol-2-yl)-2-pentene-1,5-dicarboxylate

There total 1 articles about diethyl 3-amino-2-cyano-4-(3'-phenyl-4'-hydroxythiazol-2-yl)-2-pentene-1,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl 3-amino-2-cyano-2-pentene-1,5-dicarboxylate (89779-30-6) + phenyl isothiocyanate (103-72-0) + chloroacetic acid ethyl ester (105-39-5) → diethyl 3-amino-2-cyano-4-(3'-phenyl-4'-hydroxythiazol-2-yl)-2-pentene-1,5-dicarboxylate (142168-47-6)

Guidance literature:

With potassium hydroxide; Yield given. Multistep reaction; 1) DMF, room temperature, overnight, 2) room temperature, 24 h;

DOI:10.1007/BF00810946

Reference yield: 68.0%

diethyl 3-amino-2-cyano-4-(3'-phenyl-4'-hydroxythiazol-2-yl)-2-pentene-1,5-dicarboxylate (142168-47-6) → ethyl (3-amino-4-ethoxycarbonyl-isoxazolo-5-yl)-α-(4'-hydroxy-3'-phenyl-thiazolo-2'-yl)-acetate (142168-49-8)

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; In ethanol; for 6h; Heating;

DOI:10.1007/BF00810946

Reference yield: 65.0%

diethyl 3-amino-2-cyano-4-(3'-phenyl-4'-hydroxythiazol-2-yl)-2-pentene-1,5-dicarboxylate (142168-47-6) → ethyl 3-amino-2-cyano-3-hydrazido-4-(4'-hydroxy-3'-phenylthiazol-2'-yl)-crotonoate

Guidance literature:

With hydrazine hydrate; In ethanol; for 4h; Heating;

DOI:10.1007/BF00810946

upstream raw materials:

diethyl 3-amino-2-cyano-2-pentene-1,5-dicarboxylate

phenyl isothiocyanate

chloroacetic acid ethyl ester

Downstream raw materials:

ethyl (3-amino-4-ethoxycarbonyl-isoxazolo-5-yl)-α-(4'-hydroxy-3'-phenyl-thiazolo-2'-yl)-acetate

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