N-<2-amino>benzoyl>-L-glutamic acid

Base Information

• Chemical Name: N-<2-amino>benzoyl>-L-glutamic acid
• CAS No.: 112113-77-6
• Molecular Formula: C₁₉H₂₀N₈O₅
• Molecular Weight: 440.418

Synonyms:N-<2-amino>benzoyl>-L-glutamic acid

Chemical Property of N-<2-amino>benzoyl>-L-glutamic acid

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Technology Process of N-<2-amino>benzoyl>-L-glutamic acid

There total 4 articles about N-<2-amino>benzoyl>-L-glutamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-glutamic acid 5-tert-butyl 1-methyl ester hydrochloride (6234-01-1,16948-36-0) → N-<2-amino>benzoyl>-L-glutamic acid (112113-77-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / Et₃N / CH₂Cl₂ / 3 h / 25 °C

2: 96 percent / hydrogen / 10percent platinum/carbon / ethanol; acetic acid / 3 h

3: 1.) Br₂, Ph₃P, N,N-dimethylacetamide, 2.) BaO / 1.) 25 deg C, 18 h, 2.) 55 deg C, 24 h

With N,N-dimethyl acetamide; hydrogen; bromine; triethylamine; triphenylphosphine; barium(II) oxide; platinum on activated charcoal; In ethanol; dichloromethane; acetic acid;

DOI:10.1021/jm00399a013

Reference yield:

α-methyl γ-tert-butyl N-(o-nitrobenzoyl)-L-glutamate (112113-83-4) → N-<2-amino>benzoyl>-L-glutamic acid (112113-77-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / hydrogen / 10percent platinum/carbon / ethanol; acetic acid / 3 h

2: 1.) Br₂, Ph₃P, N,N-dimethylacetamide, 2.) BaO / 1.) 25 deg C, 18 h, 2.) 55 deg C, 24 h

With N,N-dimethyl acetamide; hydrogen; bromine; triphenylphosphine; barium(II) oxide; platinum on activated charcoal; In ethanol; acetic acid;

DOI:10.1021/jm00399a013

Reference yield:

2-nitrobenzyl chloride (610-14-0) → N-<2-amino>benzoyl>-L-glutamic acid (112113-77-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / Et₃N / CH₂Cl₂ / 3 h / 25 °C

2: 96 percent / hydrogen / 10percent platinum/carbon / ethanol; acetic acid / 3 h

3: 1.) Br₂, Ph₃P, N,N-dimethylacetamide, 2.) BaO / 1.) 25 deg C, 18 h, 2.) 55 deg C, 24 h

With N,N-dimethyl acetamide; hydrogen; bromine; triethylamine; triphenylphosphine; barium(II) oxide; platinum on activated charcoal; In ethanol; dichloromethane; acetic acid;

DOI:10.1021/jm00399a013

upstream raw materials:

2,4-diamino-6-(hydroxymethyl)pteridine

α-methyl γ-tert-butyl N-(o-aminobenzoyl)-L-glutamate hydrochloride

L-glutamic acid 5-tert-butyl 1-methyl ester hydrochloride

α-methyl γ-tert-butyl N-(o-nitrobenzoyl)-L-glutamate

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