ethyl 2-chloro-5-isobutoxybenzoate

Base Information

• Chemical Name: ethyl 2-chloro-5-isobutoxybenzoate
• CAS No.: 1621681-46-6
• Molecular Formula: C₁₃H₁₇ClO₃
• Molecular Weight: 256.729
• Mol file: 1621681-46-6.mol

Synonyms:ethyl 2-chloro-5-isobutoxybenzoate

Chemical Property of ethyl 2-chloro-5-isobutoxybenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-chloro-5-isobutoxybenzoate

There total 1 articles about ethyl 2-chloro-5-isobutoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

Isobutyl bromide (78-77-3) + 2-chloro-5-hydroxybenzoic acid ethyl ester (39062-63-0) → ethyl 2-chloro-5-isobutoxybenzoate (1621681-46-6)

Guidance literature:

With caesium carbonate; In acetonitrile; Reflux;

Reference yield: 100.0%

ethyl 2-chloro-5-isobutoxybenzoate (1621681-46-6) → 2-chloro-5-isobutoxybenzoic acid (1237079-75-2)

Guidance literature:

With water; sodium hydroxide; In methanol; for 4h; Reflux;

Reference yield:

ethyl 2-chloro-5-isobutoxybenzoate (1621681-46-6) → 4-(2-chloro-5-isobutoxybenzamido)-3,5-dimethylbenzoic acid (1621680-91-8)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydroxide; water / methanol / 4 h / Reflux

2: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 20 °C

3: potassium carbonate / tetrahydrofuran / 0 - 20 °C

4: sodium hydroxide; water / tetrahydrofuran / 80 °C

With oxalyl dichloride; water; potassium carbonate; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; methanol;

upstream raw materials:

Isobutyl bromide

2-chloro-5-hydroxybenzoic acid ethyl ester

Downstream raw materials:

4-(2-chloro-5-isobutoxybenzamido)-3,5-dimethylbenzoic acid

2-chloro-5-isobutoxybenzoic acid

4-(2-chloro-5-isobutoxy-N-methylbenzamido)-3,5-dimethylbenzoic acid