4-amino-6-(4-(1-amino-2-methylpropan-2-yl)phenyl)-2-methoxy-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one

Base Information

• Chemical Name: 4-amino-6-(4-(1-amino-2-methylpropan-2-yl)phenyl)-2-methoxy-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one
• CAS No.: 1236410-57-3
• Molecular Formula: C₁₈H₂₃N₅O₂
• Molecular Weight: 341.413

Synonyms:4-amino-6-(4-(1-amino-2-methylpropan-2-yl)phenyl)-2-methoxy-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one

Chemical Property of 4-amino-6-(4-(1-amino-2-methylpropan-2-yl)phenyl)-2-methoxy-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one

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Technology Process of 4-amino-6-(4-(1-amino-2-methylpropan-2-yl)phenyl)-2-methoxy-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one

There total 1 articles about 4-amino-6-(4-(1-amino-2-methylpropan-2-yl)phenyl)-2-methoxy-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[4-(4-amino-2-methoxy-5-oxo-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)phenyl]-2-methylpropanenitrile (1236408-29-9) → 4-amino-6-(4-(1-amino-2-methylpropan-2-yl)phenyl)-2-methoxy-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one (1236410-57-3)

Guidance literature:

With ammonia; hydrogen; Raney nickel; In methanol; water; at 20 - 30 ℃; for 69h; under 37503.8 Torr;

Reference yield: 55.0%

4-amino-6-(4-(1-amino-2-methylpropan-2-yl)phenyl)-2-methoxy-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one (1236410-57-3) + acetyl chloride (75-36-5) → N-{2-[4-(4-amino-2-methoxy-5-oxo-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)phenyl]-2-methylpropyl}acetamide (1236408-38-0)

Guidance literature:

With triethylamine; In dichloromethane; at 10 - 20 ℃; for 2.05h;

Reference yield: 44.0%

di-tert-butyl dicarbonate (24424-99-5) + 4-amino-6-(4-(1-amino-2-methylpropan-2-yl)phenyl)-2-methoxy-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one (1236410-57-3) → tert-butyl {2-[4-(4-amino-2-methoxy-5-oxo-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)phenyl]-2-methylpropyl}carbamate (1236408-37-9)

Guidance literature:

In dichloromethane; at 20 ℃; for 16h;

upstream raw materials:

2-[4-(4-amino-2-methoxy-5-oxo-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)phenyl]-2-methylpropanenitrile

Downstream raw materials:

N-{2-[4-(4-amino-2-methoxy-5-oxo-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)phenyl]-2-methylpropyl}acetamide

tert-butyl {2-[4-(4-amino-2-methoxy-5-oxo-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)phenyl]-2-methylpropyl}carbamate

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