(+)-(6R,7R,SS)-1,2,3,5,6,7-hexahydro-6-<2-(isopropoxycarbonyl)-1-methylethyl>-7-methyl-8-<(4-methylphenyl)sulfinyl>-5-indolizinone

Base Information

Chemical Name:(+)-(6R,7R,SS)-1,2,3,5,6,7-hexahydro-6-<2-(isopropoxycarbonyl)-1-methylethyl>-7-methyl-8-<(4-methylphenyl)sulfinyl>-5-indolizinone
CAS No.:137008-15-2
Molecular Formula:C₂₃H₃₁NO₄S
Molecular Weight:417.569
Hs Code.:

Synonyms:(+)-(6R,7R,SS)-1,2,3,5,6,7-hexahydro-6-<2-(isopropoxycarbonyl)-1-methylethyl>-7-methyl-8-<(4-methylphenyl)sulfinyl>-5-indolizinone

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Chemical Property of (+)-(6R,7R,SS)-1,2,3,5,6,7-hexahydro-6-<2-(isopropoxycarbonyl)-1-methylethyl>-7-methyl-8-<(4-methylphenyl)sulfinyl>-5-indolizinone

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Technology Process of (+)-(6R,7R,SS)-1,2,3,5,6,7-hexahydro-6-<2-(isopropoxycarbonyl)-1-methylethyl>-7-methyl-8-<(4-methylphenyl)sulfinyl>-5-indolizinone

There total 2 articles about (+)-(6R,7R,SS)-1,2,3,5,6,7-hexahydro-6-<2-(isopropoxycarbonyl)-1-methylethyl>-7-methyl-8-<(4-methylphenyl)sulfinyl>-5-indolizinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6284-46-4
isopropyl crotonate

: 123642-79-5
(+)-(R)-4,5-dihydro-2-<<(4-methylphenyl)sulfinyl>methyl>-3H-pyrrole

: 137008-15-2
(+)-(6R,7R,SS)-1,2,3,5,6,7-hexahydro-6-<2-(isopropoxycarbonyl)-1-methylethyl>-7-methyl-8-<(4-methylphenyl)sulfinyl>-5-indolizinone

: 137119-54-1,129762-22-7
(-)-(7R,SS)-1,2,3,5,6,7-hexahydro-7-methyl-8-<(4-methylphenyl)sulfinyl>-5-indolizinone

Guidance literature:: With lithium diisopropyl amide; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, -78 deg C, 1 h, 2.) a) -78 deg C, b) 25 deg C, 2 h;
DOI:10.1021/jo00025a011

Reference yield:

: 1519-39-7
(R)-methyl p-tolyl sulfoxide

: 137008-15-2
(+)-(6R,7R,SS)-1,2,3,5,6,7-hexahydro-6-<2-(isopropoxycarbonyl)-1-methylethyl>-7-methyl-8-<(4-methylphenyl)sulfinyl>-5-indolizinone

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) ethylmagnesium bromide, diisopropylamine / 1.) THF, 0 deg C, 45 min, 2.) HMPA, 0 deg C, 30 min

2: 1.) LDA / 1.) THF, -78 deg C, 1 h, 2.) a) -78 deg C, b) 25 deg C, 2 h

With ethylmagnesium bromide; diisopropylamine; lithium diisopropyl amide;
DOI:10.1021/jo00025a011