6284-46-4

Usage

Uses

Used in Flavor and Fragrance Industry:
Crotonic acid isopropyl ester is used as a flavoring agent for its fruity odor, adding depth and complexity to various food and beverage products.
Used in Chemical Production:
Isopropyl crotonate is utilized as a solvent and intermediate in the synthesis of other chemicals, contributing to the manufacturing processes of pharmaceuticals and agricultural products.
Used in Pharmaceutical Industry:
Crotonic acid isopropyl ester is used as a chemical intermediate in the production of pharmaceuticals, aiding in the development of new medications and enhancing the efficacy of existing ones.
Used in Agricultural Products:
In the agricultural sector, isopropyl crotonate is employed as a component in the formulation of various products, potentially improving crop yields and protection against pests.

InChI:InChI=1/C7H12O2/c1-4-5-7(8)9-6(2)3/h4-6H,1-3H3/b5-4+

Upstream product

• 3724-65-0 2-butenoic acid 
• 67-63-0 isopropyl alcohol 
• 625-35-4 trans-chrotonyl chloride 
• 107-93-7 (E)-but-2-enoic acid 
• 153854-02-5 (R)-3-acetoxybutyric acid methyl ester 

Downstream Products

• 127322-74-1 isopropyl (2E)-4-bromobut-2-enoate 
• 56783-10-9 (2R,3S,3aS)-2-Methyl-hexahydro-pyrrolo[1,2-b]isoxazole-3-carboxylic acid methyl ester 
• 56783-10-9 (2R,3S,3aR)-2-Methyl-hexahydro-pyrrolo[1,2-b]isoxazole-3-carboxylic acid methyl ester 
• 141633-06-9 (2R,3S,3aS)-2-Methyl-hexahydro-pyrrolo[1,2-b]isoxazole-3-carboxylic acid isopropyl ester 
• 141633-06-9 (2R,3S,3aR)-2-Methyl-hexahydro-pyrrolo[1,2-b]isoxazole-3-carboxylic acid isopropyl ester 
• 141633-09-2 (2R,3S,3aS)-2-Methyl-hexahydro-isoxazolo[2,3-a]pyridine-3-carboxylic acid isopropyl ester 
• 141633-09-2 (2R,3S,3aR)-2-Methyl-hexahydro-isoxazolo[2,3-a]pyridine-3-carboxylic acid isopropyl ester 
• 103233-41-6 i-Propyl-dihydro-orsellinat 
• 104937-97-5 5-Benzenesulfonylamino-3-methyl-5-oxo-4-phenyl-pentanoic acid isopropyl ester 
• 137008-15-2 (+)-(6R,7R,SS)-1,2,3,5,6,7-hexahydro-6-<2-(isopropoxycarbonyl)-1-methylethyl>-7-methyl-8-<(4-methylphenyl)sulfinyl>-5-indolizinone 
• 137119-54-1 (-)-(7R,SS)-1,2,3,5,6,7-hexahydro-7-methyl-8-<(4-methylphenyl)sulfinyl>-5-indolizinone 
• 141633-13-8 (2R,3R,3aR)-3-Methyl-octahydro-isoxazolo[2,3-a]azepine-2-carboxylic acid isopropyl ester 
• 141633-13-8 (2R,3R,3aS)-3-Methyl-octahydro-isoxazolo[2,3-a]azepine-2-carboxylic acid isopropyl ester 
• 141633-11-6 (2R,3S,3aS)-2-Methyl-octahydro-isoxazolo[2,3-a]azepine-3-carboxylic acid isopropyl ester 

Relevant academic research and scientific papers

Rational Synthesis of Metallo-Cations Toward Redox- A nd Alkaline-Stable Metallo-Polyelectrolytes

Cations are crucial components in emerging functional polyelectrolytes for a myriad of applications. Rapid development in this area necessitates the exploration of new cations with advanced properties. Herein we describe a combination of computational and experimental design of cobaltocene metallo-cations that have distinct electronic and redox properties. One of the direct outcomes on the first synthesis of a complete set of cation derivatives is to discover highly stable cations, which are further integrated to construct metallo-polyelectrolytes as anion-exchange membranes in solid-state alkaline fuel cells. The device performance of these polyelectrolytes under highly basic and oxidative environments is competitive with many organo-polyelectrolytes.

The role of neutral donor ligands in the isoselective ring-opening polymerization of: Rac -β-butyrolactone

Isoenriched poly-3-hydroxybutyrate (P3HB) is a biodegradable material with properties similar to isotactic polypropylene, yet efficient routes to this material are lacking after 50+ years of extensive efforts in catalyst design. In this contribution, a novel lanthanum aminobisphenolate catalyst (1-La) can access isoenriched P3HB through the stereospecific ring-opening polymerization (ROP) of rac-β-butyrolactone (rac-BBL). Replacing the tethered donor group of a privileged supporting ligand with a non-coordinating benzyl substituent generates a catalyst whose reactivity and selectivity can be tuned with inexpensive achiral neutral donor ligands (e.g. phosphine oxides, OPR3). The 1-La/OPR3 (R = n-octyl, Ph) systems display high activity and are the most isoselective homogeneous catalysts for the ROP of rac-BBL to date (0 °C: Pm = 0.8, TOF ～190 h-1). Combined reactivity and spectroscopic studies provide insight into the active catalyst structure and ROP mechanism. Both 1-La(TPPO)2 and a structurally related catalyst with a tethered donor group (2-Y) operate under chain-end stereocontrol; however, 2-RE favors formation of P3HB with opposite tacticity (syndioenriched) and its ROP activity and selectivity are totally unaffected by added neutral donor ligands. Our studies uncover new roles for neutral donor ligands in stereospecific ROP, including suppression of chain-scission events, and point to new opportunities for catalyst design. This journal is

METHODS FOR PREPARING COPOLYMERS OF ETHYLENE AND α-OLEFINS USING ADVANCED TRANSITION METAL CATALYTIC SYSTEMS

Provided is a homogeneous catalytic system for use in preparing an ethylene homopolymer or a copolymer of ethylene and α-olefin, and more particularly a Group 4 transition metal compound in which a cyclopentadienyl derivative 3,4-positions of which are substituted with alkyls and an electron-donating substituent are crosslinked around a Group 4 transition metal. Also provided is a method of preparing an ethylene homopolymer or a copolymer of ethylene andα-olefin, having high molecular weight, under high-temperature solution polymerization conditions using the catalytic system including such a transition metal compound and a co-catalyst composed of an aluminum compound, a boron compound or a mixture thereof. The catalyst according to present invention has high thermal stability and enables the incorporation of α-olefin, and is thus effective in preparing an ethylene homopolymer or a copolymer of ethylene and α-olefin, having various properties, in industrial polymerization processes.

Multigramme synthesis and asymmetric dihydroxylation of a 4-fluorobut-2E-enoate

Esters of crotonic acid were brominated on a multigramme scale using a free radical procedure. A phase transfer catalysed fluorination transformed these species to the 4-fluorobut-2E-enoates reproducibly and at scale (48-53%, ca. 300 mmol). Asymmetric dihydroxylation reactions were then used to transform the butenoate, ultimately into all four diastereoisomers of a versatile fluorinated C4 building block at high enantiomeric-enrichment. The (DHQ) 2AQN and (DHQD)2AQN ligands described by Sharpless were the most effective. The development and optimisation of a new and facile method for the determination of ee is also described; 19F{1H} spectra recorded in d-chloroform/diisopropyl tartrate showed distinct baseline separated signals for different enantiomers.

ADVANCED TRANSITION METAL CATALYTIC SYSTEMS IN TERMS OF COMONOMER INCORPORATIONS AND METHODS FOR PREPARING ETHYLENE HOMOPOLYMERS OR COPOLYMERS OF ETHYLENE AND A-OLEFINS USING THE SAME

Provided is a homogeneous catalytic system for use in preparing an ethylene homopolymer or a copolymer of ethylene and α-olefin, and more particularly a Group 4 transition metal compound in which a cyclopentadienyl derivative 3,4-positions of which are substituted with alkyls and an electron-donating substituent are crosslinked around a Group 4 transition metal. Also provided is a method of preparing an ethylene homopolymer or a copolymer of ethylene and α-olefin, having high molecular weight, under high-temperature solution polymerization conditions using the catalytic system including such a transition metal compound and a co-catalyst composed of an aluminum compound, a boron compound or a mixture thereof. The catalyst according to present invention has high thermal stability and enables the incorporation of α-olefin, and is thus effective in preparing an ethylene homopolymer or a copolymer of ethylene and α-olefin, having various properties, in industrial polymerization processes.

Zinc promoted mild and efficient method for the esterification of acid chlorides with alcohols

The esterification of variety of acid chlorides with alcohols in the presence of zinc is described. The easy formation of t-butyl and pivaloyl esters are the additional importance of this procedure.

A VERSATILE ROUTE TO MIXED VINYLKETENE ACETALS : USE OF 1-t-BUTYLDIMETHYLSILOXY-1-ETHOXY BUTADIENE IN CYCLOHEXENONE SYNTHESIS

The successful entry to the diverse mixed vinylketene acetals 3 extends the participation of these intermediates in cyclohexenone synthesis.