4-(2-fluoro-4-nitrophenoxy)-N-(3-((methylsulfonyl)methyl)phenyl)pyrimidin-2-amine

Base Information

Chemical Name:4-(2-fluoro-4-nitrophenoxy)-N-(3-((methylsulfonyl)methyl)phenyl)pyrimidin-2-amine
CAS No.:1584220-19-8
Molecular Formula:C₁₈H₁₅FN₄O₅S
Molecular Weight:418.405
Hs Code.:

Synonyms:4-(2-fluoro-4-nitrophenoxy)-N-(3-((methylsulfonyl)methyl)phenyl)pyrimidin-2-amine

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Chemical Property of 4-(2-fluoro-4-nitrophenoxy)-N-(3-((methylsulfonyl)methyl)phenyl)pyrimidin-2-amine

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Technology Process of 4-(2-fluoro-4-nitrophenoxy)-N-(3-((methylsulfonyl)methyl)phenyl)pyrimidin-2-amine

There total 1 articles about 4-(2-fluoro-4-nitrophenoxy)-N-(3-((methylsulfonyl)methyl)phenyl)pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 868733-43-1
2-chloro-4-(2-fluoro-4-nitrophenoxy)pyrimidine

: 261925-02-4
3-((methylsulfonyl)methyl)aniline

: 1584220-19-8
4-(2-fluoro-4-nitrophenoxy)-N-(3-((methylsulfonyl)methyl)phenyl)pyrimidin-2-amine

Guidance literature:: With toluene-4-sulfonic acid; In 1,4-dioxane; at 90 ℃; Sealed tube;
DOI:10.1021/ml500066m

Reference yield: 97.0%

: 1584220-19-8
4-(2-fluoro-4-nitrophenoxy)-N-(3-((methylsulfonyl)methyl)phenyl)pyrimidin-2-amine

: 1584220-15-4
4-(4-amino-2-fluorophenoxy)-N-(3-((methylsulfonyl)methyl)phenyl)pyrimidin-2-amine

Guidance literature:: With iron; ammonium chloride; In ethanol; water; at 70 ℃; for 2h;
DOI:10.1021/ml500066m

Reference yield:

: 1584220-19-8
4-(2-fluoro-4-nitrophenoxy)-N-(3-((methylsulfonyl)methyl)phenyl)pyrimidin-2-amine

: 1584219-90-8
N-(3-fluoro-4-((2-((3-((methylsulfonyl)methyl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)-N'-(4-chloro-3-(trifluoromethyl)phenyl)cyclopropane-1,1-dicarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: iron; ammonium chloride / water; ethanol / 2 h / 70 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide

With iron; ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/ml500066m