1584220-15-4

Basic information

• Product Name: 4-(4-amino-2-fluorophenoxy)-N-(3-((methylsulfonyl)methyl)phenyl)pyrimidin-2-amine
• Synonyms: 4-(4-amino-2-fluorophenoxy)-N-(3-((methylsulfonyl)methyl)phenyl)pyrimidin-2-amine
• CAS NO: 1584220-15-4
• Molecular Weight: 388.422
• Mol File: 1584220-15-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(4-amino-2-fluorophenoxy)-N-(3-((methylsulfonyl)methyl)phenyl)pyrimidin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-amino-2-fluorophenoxy)-N-(3-((methylsulfonyl)methyl)phenyl)pyrimidin-2-amine(1584220-15-4)
• EPA Substance Registry System: 4-(4-amino-2-fluorophenoxy)-N-(3-((methylsulfonyl)methyl)phenyl)pyrimidin-2-amine(1584220-15-4)

Safety Data

• Hazardous Substances Data: 1584220-15-4(Hazardous Substances Data)

Upstream product

• 868733-43-1 2-chloro-4-(2-fluoro-4-nitrophenoxy)pyrimidine 
• 1584220-19-8 4-(2-fluoro-4-nitrophenoxy)-N-(3-((methylsulfonyl)methyl)phenyl)pyrimidin-2-amine 
• 261925-02-4 3-((methylsulfonyl)methyl)aniline 

Downstream Products

• 1584219-86-2 N-(3-fluoro-4-((2-((3-((methylsulfonyl)methyl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)-N'-phenylcyclopropane-1,1-dicarboxamide 
• 1584219-81-7 N-(3-fluoro-4-((2-((3-((methylsulfonyl)methyl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 
• 1584219-82-8 N-(3-fluoro-4-((2-((3-((methylsulfonyl)methyl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)-N'-(4-bromophenyl)cyclopropane-1,1-dicarboxamide 
• 1584219-83-9 N-(3-fluoro-4-((2-((3-((methylsulfonyl)methyl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)-N'-(4-methoxyphenyl)cyclopropane-1,1-dicarboxamide 
• 1584219-84-0 N-(3-fluoro-4-((2-((3-((methylsulfonyl)methyl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)-N'-(3-methoxyphenyl)cyclopropane-1,1-dicarboxamide 
• 1584219-85-1 N-(3-fluoro-4-((2-((3-((methylsulfonyl)methyl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)-N'-(m-tolyl)cyclopropane-1,1-dicarboxamide 
• 1584219-87-3 N-(3-fluoro-4-((2-((3-((methylsulfonyl)methyl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)-N'-(3-fluorophenyl)cyclopropane-1,1-dicarboxamide 
• 1584219-88-4 N-(3-fluoro-4-((2-((3-((methylsulfonyl)methyl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)-N'-(3-chlorophenyl)cyclopropane-1,1-dicarboxamide 
• 1584219-89-5 N-(3-fluoro-4-((2-((3-((methylsulfonyl)methyl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)-N'-(3-(trifluoromethyl)phenyl)cyclopropane-1,1-dicarboxamide 
• 1584219-90-8 N-(3-fluoro-4-((2-((3-((methylsulfonyl)methyl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)-N'-(4-chloro-3-(trifluoromethyl)phenyl)cyclopropane-1,1-dicarboxamide 
• 1584219-91-9 N-(3-fluoro-4-((2-((3-((methylsulfonyl)methyl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)-N'-(4-cyano-3-(trifluoromethyl)phenyl)cyclopropane-1,1-dicarboxamide 

Relevant articles and documents

Discovery of anilinopyrimidines as dual inhibitors of c-Met and VEGFR-2: Synthesis, SAR, and cellular activity

Both c-Met and VEGFR-2 are important targets for cancer therapies. Here we report a series of potent dual c-Met and VEGFR-2 inhibitors bearing an anilinopyrimidine scaffold. Two novel synthetic protocols were employed for rapid analoguing of the designed