5-tert-butyl-2-hydroxybenzyl bromide

Base Information

• Chemical Name: 5-tert-butyl-2-hydroxybenzyl bromide
• CAS No.: 1034518-96-1
• Molecular Formula: C₁₁H₁₅BrO
• Molecular Weight: 243.143
• Mol file: 1034518-96-1.mol

Synonyms:5-tert-butyl-2-hydroxybenzyl bromide

Chemical Property of 5-tert-butyl-2-hydroxybenzyl bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 5-tert-butyl-2-hydroxybenzyl bromide

There total 3 articles about 5-tert-butyl-2-hydroxybenzyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-(tert-butyl)-2-(hydroxymethyl)phenol (6638-87-5) → 5-tert-butyl-2-hydroxybenzyl bromide (1034518-96-1)

Guidance literature:

With phosphorus tribromide; In chloroform; at 20 ℃; Inert atmosphere;

DOI:10.1039/b926864b

Reference yield:

para-tert-butylphenol (98-54-4) → 5-tert-butyl-2-hydroxybenzyl bromide (1034518-96-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tributyl-amine; tin(IV) chloride / toluene / 20 °C / Inert atmosphere

1.2: 100 °C / Inert atmosphere

2.1: sodium tetrahydroborate / methanol / 20 °C / Inert atmosphere

3.1: phosphorus tribromide / chloroform / 20 °C / Inert atmosphere

With sodium tetrahydroborate; tributyl-amine; phosphorus tribromide; tin(IV) chloride; In methanol; chloroform; toluene;

DOI:10.1039/b926864b

Reference yield:

2-hydroxy-5-t-butylbenzaldehyde (2725-53-3) → 5-tert-butyl-2-hydroxybenzyl bromide (1034518-96-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 20 °C / Inert atmosphere

2: phosphorus tribromide / chloroform / 20 °C / Inert atmosphere

With sodium tetrahydroborate; phosphorus tribromide; In methanol; chloroform;

DOI:10.1039/b926864b

upstream raw materials:

4-(tert-butyl)-2-(hydroxymethyl)phenol

para-tert-butylphenol

2-hydroxy-5-t-butylbenzaldehyde

Downstream raw materials:

[N-(5-tert-butyl-2-hydroxybenzyl)-N,N-di(2-pyridylmethyl)]amine

2-[bis(5-tert-butyl-2-hydroxybenzyl)aminomethyl]-pyridine