2725-53-3Relevant articles and documents
A novel axially palladium(II)-Schiff base complex substituted silicon(IV) phthalocyanine: Synthesis, characterization, photophysicochemical properties and photodynamic antimicrobial chemotherapy activity against Staphylococcus aureus
Sen, Pinar,Nyokong, Tebello
, (2019)
In this study, a novel silicon(IV) phthalocyanine is reported for the first time as a phthalocyanine derivative bearing axially a palladium(II)-Schiff base complex. The photophysical and photochemical properties of the new Si(IV)Pc, such as absorption, fluorescence, singlet oxygen quantum yields, triplet state quantum yields and exited state lifetimes were measured in DMSO. The new silicon phthalocyanine displayed very low fluorescence, showing efficient intersystem crossing resulting in high triplet and high singlet oxygen quantum yields in DMSO. When compared with the unsubstituted SiPcCl2, the singlet oxygen quantum yield value (ΦΔ = 0.47) in relation to the triplet quantum yield (ΦT = 0.82), which is an important determinant for PDT applications, increased. The photodynamic antimicrobial chemotherapy activity (PACT) of new Si(IV)Pc towards Staphylococcus aureus was determined in comparison to the unsubstituted SiPcCl2. The results of the photodynamic antimicrobial effect study demonstrated that the Pd(II) complex substituted SiPc (5) possesses excellent photodynamic activity with a reduction percentage value of 99.94% and a log red value of 3.26.
Zwitterionic macrocyclic metal sulfate extractants containing 3-dialkylaminomethylsalicylaldimine units
Plieger, Paul G.,Tasker, Peter A.,Galbraith, Stuart G.
, p. 313 - 318 (2004)
10,25-Di-tert-alkyl-14,21-dimethyl-3,6,14,21-tetraazatricyclo[21.3.1.18, 12]octacosa-1(27),2,6,8,10,12(28),23,25-octaene-27,28-diol macrocycles form Ni(II) and Cu(II) complexes in which the metal cation and the sulfate anion are bound in separated sites in a zwitterionic form of the ligand. The nonyl-substituted macrocycle shows a higher affinity for SO42- and a lower binding strength for Cu2+ than open chain analogues, the pH-dependences for which fall in ranges which allow loading of CuSO4 at pH ≈4 and easy stripping to recycle the ligand. X-Ray structure determinations of the Cu(II) and Ni(II) sulfate complexes of the tert-butyl substituted ligand suggest that the de-tuning of M2+-binding results from a distortion from planarity of the "salen" N2O22- donor set imposed by the incorporation of the hexamethylene strap in the ligand and reveal that the sulfate is bound as a hydrate in a 2:2:2:2, ligand-M2+-SO42--H2O, assembly.
Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction
Chessari, Gianni,Hardcastle, Ian R.,Ahn, Jong Sook,Anil, Burcu,Anscombe, Elizabeth,Bawn, Ruth H.,Bevan, Luke D.,Blackburn, Timothy J.,Buck, Ildiko,Cano, Celine,Carbain, Benoit,Castro, Juan,Cons, Ben,Cully, Sarah J.,Endicott, Jane A.,Fazal, Lynsey,Golding, Bernard T.,Griffin, Roger J.,Haggerty, Karen,Harnor, Suzannah J.,Hearn, Keisha,Hobson, Stephen,Holvey, Rhian S.,Howard, Steven,Jennings, Claire E.,Johnson, Christopher N.,Lunec, John,Miller, Duncan C.,Newell, David R.,Noble, Martin E. M.,Reeks, Judith,Revill, Charlotte H.,Riedinger, Christiane,St. Denis, Jeffrey D.,Tamanini, Emiliano,Thomas, Huw,Thompson, Neil T.,Vinkovi?, Mladen,Wedge, Stephen R.,Williams, Pamela A.,Wilsher, Nicola E.,Zhang, Bian,Zhao, Yan
supporting information, p. 4071 - 4088 (2021/05/04)
Inhibition of murine double minute 2 (MDM2)-p53 protein-protein interaction with small molecules has been shown to reactivate p53 and inhibit tumor growth. Here, we describe rational, structure-guided, design of novel isoindolinone-based MDM2 inhibitors. MDM2 X-ray crystallography, quantum mechanics ligand-based design, and metabolite identification all contributed toward the discovery of potent in vitro and in vivo inhibitors of the MDM2-p53 interaction with representative compounds inducing cytostasis in an SJSA-1 osteosarcoma xenograft model following once-daily oral administration.
Unprecedented reductive cyclisation of salophen ligands to tetrahydroquinoxalines during metal complex formation
Dowsett, Mark R.,Lamb, Katie J.,North, Michael,Parker, Rachel R.,Whitwood, Adrian C.
supporting information, p. 4844 - 4847 (2020/05/13)
The synthesis of novel tetrahydroquinoxalines by a metal induced one-electron reductive cyclisation of salophen ligands was found to occur when a salophen ligand was treated with chromium(ii) chloride or decamethylcobaltocene.
Phosphine-Catalyzed [3+2] Annulation of β-Sulfonamido-Substituted Enones with Sulfamate-Derived Cyclic Imines
Shi, Wangyu,Zhou, Leijie,Mao, Biming,Wang, Qijun,Wang, Chang,Zhang, Cheng,Li, Xuefeng,Xiao, Yumei,Guo, Hongchao
supporting information, p. 679 - 685 (2019/01/24)
Phosphine-catalyzed [3+2] annulation of β-sulfonamido-substituted enones and sulfamate-derived cyclic imines has been developed, giving a series of imidazoline derivatives in moderate to excellent yields with good to excellent diastereoselectivities. A scale-up reaction worked well under mild reaction conditions. A possible mechanism was proposed on the basis of the results obtained.
