tert-butyl (5-(((3S)-4-(4-(1-hydroxy-1-(trifluoromethyl)-3-butyn-1-yl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)-sulfonyl)-2-pyridinyl)carbamate

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Chemical Name:tert-butyl (5-(((3S)-4-(4-(1-hydroxy-1-(trifluoromethyl)-3-butyn-1-yl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)-sulfonyl)-2-pyridinyl)carbamate
CAS No.:1572928-69-8
Molecular Formula:C₂₈H₃₁F₃N₄O₅S
Molecular Weight:592.639
Hs Code.:

Synonyms:tert-butyl (5-(((3S)-4-(4-(1-hydroxy-1-(trifluoromethyl)-3-butyn-1-yl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)-sulfonyl)-2-pyridinyl)carbamate

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Chemical Property of tert-butyl (5-(((3S)-4-(4-(1-hydroxy-1-(trifluoromethyl)-3-butyn-1-yl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)-sulfonyl)-2-pyridinyl)carbamate

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Technology Process of tert-butyl (5-(((3S)-4-(4-(1-hydroxy-1-(trifluoromethyl)-3-butyn-1-yl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)-sulfonyl)-2-pyridinyl)carbamate

There total 23 articles about tert-butyl (5-(((3S)-4-(4-(1-hydroxy-1-(trifluoromethyl)-3-butyn-1-yl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)-sulfonyl)-2-pyridinyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1572928-04-1
tert-butyl (5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2-(trifluoromethyl)-2-oxiranyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

: 1066-54-2
trimethylsilylacetylene

: 1572928-69-8
tert-butyl (5-(((3S)-4-(4-(1-hydroxy-1-(trifluoromethyl)-3-butyn-1-yl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)-sulfonyl)-2-pyridinyl)carbamate

Guidance literature:: trimethylsilylacetylene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

tert-butyl (5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2-(trifluoromethyl)-2-oxiranyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 20.1667h;

Reference yield:

: C₃₁H₃₉F₃N₄O₅SSi

: 1572928-69-8
tert-butyl (5-(((3S)-4-(4-(1-hydroxy-1-(trifluoromethyl)-3-butyn-1-yl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)-sulfonyl)-2-pyridinyl)carbamate

Guidance literature:: With potassium carbonate; In methanol; at 20 ℃; for 2h;
DOI:10.1021/jm5000497

Reference yield:

: 16184-89-7
4'-bromo-2,2,2-trifluoroacetophenone

: 1572928-69-8
tert-butyl (5-(((3S)-4-(4-(1-hydroxy-1-(trifluoromethyl)-3-butyn-1-yl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)-sulfonyl)-2-pyridinyl)carbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium tert-butylate / dimethyl sulfoxide / 0.67 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: water / 1,4-dioxane / 24 h / 85 °C

3.1: toluene-4-sulfonic acid / acetone / 40 h / 20 °C

4.1: chloro(2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl)(2′-amino-1,1′-biphenyl-2-yl)-palladium(II); sodium t-butanolate / 1,4-dioxane / 0.5 h / 80 °C / Inert atmosphere

5.1: trifluoroacetic acid; trifluorormethanesulfonic acid / 1.5 h / 20 °C

6.1: triethylamine / dichloromethane / 1 h / 20 °C

7.1: triethylamine; p-toluenesulfonyl chloride / dichloromethane / 2 h / Reflux; Inert atmosphere

8.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

8.2: 20.17 h / -78 - 20 °C

With n-butyllithium; trifluorormethanesulfonic acid; chloro(2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl)(2′-amino-1,1′-biphenyl-2-yl)-palladium(II); potassium tert-butylate; water; toluene-4-sulfonic acid; triethylamine; p-toluenesulfonyl chloride; trifluoroacetic acid; sodium t-butanolate; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; dimethyl sulfoxide; acetone;