(2S)-2-amino-3-(3,4-bis((2-(benzoyloxy)-2-methylpropanoyl)oxy)phenyl)propanoic acid hydrochloride

Base Information

Chemical Name:(2S)-2-amino-3-(3,4-bis((2-(benzoyloxy)-2-methylpropanoyl)oxy)phenyl)propanoic acid hydrochloride
CAS No.:1379613-68-9
Molecular Formula:C₃₁H₃₁NO₁₀*ClH
Molecular Weight:614.049
Hs Code.:

Synonyms:(2S)-2-amino-3-(3,4-bis((2-(benzoyloxy)-2-methylpropanoyl)oxy)phenyl)propanoic acid hydrochloride

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Chemical Property of (2S)-2-amino-3-(3,4-bis((2-(benzoyloxy)-2-methylpropanoyl)oxy)phenyl)propanoic acid hydrochloride

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Technology Process of (2S)-2-amino-3-(3,4-bis((2-(benzoyloxy)-2-methylpropanoyl)oxy)phenyl)propanoic acid hydrochloride

There total 8 articles about (2S)-2-amino-3-(3,4-bis((2-(benzoyloxy)-2-methylpropanoyl)oxy)phenyl)propanoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1379613-67-8
(2S)-3-((3,4-bis((2-benzoyloxy)-2-methylpropanoyl)oxy)phenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid

: 1379613-68-9
(2S)-2-amino-3-(3,4-bis((2-(benzoyloxy)-2-methylpropanoyl)oxy)phenyl)propanoic acid hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;

Reference yield:

: 58570-00-6
2-(benzoyloxy)-2-methylpropanoic acid

: 1379613-68-9
(2S)-2-amino-3-(3,4-bis((2-(benzoyloxy)-2-methylpropanoyl)oxy)phenyl)propanoic acid hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-dimethyl-formamide; thionyl chloride / toluene / 1 h / 70 °C / Inert atmosphere

2: triethylamine / acetonitrile / 1.25 h / Cooling with ice; Inert atmosphere

3: hydrogen; palladium 10% on activated carbon / ethanol / 2 h / 20 °C / Inert atmosphere

4: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

With hydrogenchloride; thionyl chloride; palladium 10% on activated carbon; hydrogen; triethylamine; N,N-dimethyl-formamide; In 1,4-dioxane; ethanol; toluene; acetonitrile;

Reference yield:

: 59-92-7,90638-38-3
levodopa

: 1379613-68-9
(2S)-2-amino-3-(3,4-bis((2-(benzoyloxy)-2-methylpropanoyl)oxy)phenyl)propanoic acid hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / water; tetrahydrofuran / 14 h / 20 °C / Inert atmosphere

1.2: Cooling with ice

2.1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 7 h / 20 °C / Inert atmosphere

3.1: triethylamine / acetonitrile / 1.25 h / Cooling with ice; Inert atmosphere

4.1: hydrogen; palladium 10% on activated carbon / ethanol / 2 h / 20 °C / Inert atmosphere

5.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; potassium hydrogencarbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; acetonitrile;