(1S,3R)-3-[(tert-butoxycarbonyl)amino]-2,2-dimethylcyclobutane-1-carboxylic acid

Base Information

Chemical Name:(1S,3R)-3-[(tert-butoxycarbonyl)amino]-2,2-dimethylcyclobutane-1-carboxylic acid
CAS No.:188918-50-5
Molecular Formula:C₁₂H₂₁NO₄
Molecular Weight:243.303
Hs Code.:

Synonyms:(1S,3R)-3-[(tert-butoxycarbonyl)amino]-2,2-dimethylcyclobutane-1-carboxylic acid

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Chemical Property of (1S,3R)-3-[(tert-butoxycarbonyl)amino]-2,2-dimethylcyclobutane-1-carboxylic acid

Chemical Property:

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Technology Process of (1S,3R)-3-[(tert-butoxycarbonyl)amino]-2,2-dimethylcyclobutane-1-carboxylic acid

There total 9 articles about (1S,3R)-3-[(tert-butoxycarbonyl)amino]-2,2-dimethylcyclobutane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 188918-44-7
tert-butyl [(1R,3S)-3-acetyl-2,2-dimethylcyclobutyl]carbamate

: 188918-50-5,188918-39-0,1392803-26-7
(1S,3R)-3-[(tert-butoxycarbonyl)amino]-2,2-dimethylcyclobutane-1-carboxylic acid

Guidance literature:: With sodium hypobromide; water; In 1,4-dioxane; at 0 ℃; for 3h;
DOI:10.1016/S0040-4039(97)00200-1

Reference yield: 72.6%

: 24424-99-5
di-tert-butyl dicarbonate

: 308287-83-4
(1S,3R)-(+)-3-(2-Acetamido)-2,2-dimethylcyclobutanecarboxylic acid

: 188918-50-5,188918-39-0,1392803-26-7
(1S,3R)-3-[(tert-butoxycarbonyl)amino]-2,2-dimethylcyclobutane-1-carboxylic acid

Guidance literature:: (1S,3R)-(+)-3-(2-Acetamido)-2,2-dimethylcyclobutanecarboxylic acid; With hydrogenchloride; water; for 12h; Reflux;

With sodium hydroxide; In water; pH=8 - 9;

di-tert-butyl dicarbonate; In 1,4-dioxane; at 0 - 20 ℃; for 16h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: methyl (1S,3R)-3-acetamide-2,2-dimethylcyclobutane-1-carboxylate

: 188918-50-5,188918-39-0,1392803-26-7
(1S,3R)-3-[(tert-butoxycarbonyl)amino]-2,2-dimethylcyclobutane-1-carboxylic acid

Guidance literature:: methyl (1S,3R)-3-acetamide-2,2-dimethylcyclobutane-1-carboxylate; With hydrogenchloride; In water; at 100 ℃; for 8h; Cooling with ice;

di-tert-butyl dicarbonate; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;