{[(R)-56-(benzyloxy)-1-methylpent-3-yn-1-yl]oxy}(tert-butyl)dimethylsilane

Base Information

Chemical Name:{[(R)-56-(benzyloxy)-1-methylpent-3-yn-1-yl]oxy}(tert-butyl)dimethylsilane
CAS No.:943763-59-5
Molecular Formula:C₁₉H₃₀O₂Si
Molecular Weight:318.531
Hs Code.:

Synonyms:{[(R)-56-(benzyloxy)-1-methylpent-3-yn-1-yl]oxy}(tert-butyl)dimethylsilane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of {[(R)-56-(benzyloxy)-1-methylpent-3-yn-1-yl]oxy}(tert-butyl)dimethylsilane

Chemical Property:

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Technology Process of {[(R)-56-(benzyloxy)-1-methylpent-3-yn-1-yl]oxy}(tert-butyl)dimethylsilane

There total 1 articles about {[(R)-56-(benzyloxy)-1-methylpent-3-yn-1-yl]oxy}(tert-butyl)dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 174455-52-8
(R)-6-(benzyloxy)hex-4-yn-2-ol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 943763-59-5
{[(R)-56-(benzyloxy)-1-methylpent-3-yn-1-yl]oxy}(tert-butyl)dimethylsilane

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1055/s-2007-966010

Reference yield:

: 943763-59-5
{[(R)-56-(benzyloxy)-1-methylpent-3-yn-1-yl]oxy}(tert-butyl)dimethylsilane

: (+)-({(1R,5Z,7E)-8-[(4R,6R)-6-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl]-1-methylocta-5,7-dienyl}oxy)(tert-butyl)dimethylsilane

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / H₂ / Pd/C / ethyl acetate / 12 h / 20 °C / 2844.39 Torr

2: 95 percent / DEAD; Ph₃P / tetrahydrofuran / 1 h / 20 °C

3: 88 percent / MCPBA / CH₂Cl₂ / 3 h / 20 °C

4: NaHMDS / tetrahydrofuran / 0.5 h / 20 °C

With hydrogen; sodium hexamethyldisilazane; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1055/s-2007-966010

Reference yield:

: 943763-59-5
{[(R)-56-(benzyloxy)-1-methylpent-3-yn-1-yl]oxy}(tert-butyl)dimethylsilane

: (+)-({(1R,5E,7E)-8-[(4R,6R)-6-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl]-1-methylocta-5,7-dienyl}oxy)(tert-butyl)dimethylsilane

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / H₂ / Pd/C / ethyl acetate / 12 h / 20 °C / 2844.39 Torr

2: 95 percent / DEAD; Ph₃P / tetrahydrofuran / 1 h / 20 °C

3: 88 percent / MCPBA / CH₂Cl₂ / 3 h / 20 °C

4: 78 percent / NaHMDS / tetrahydrofuran / 0.5 h / 20 °C

With hydrogen; sodium hexamethyldisilazane; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1055/s-2007-966010