4-(benzyloxy)-6-bromo-3-methyl-2-{[3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl}quinoline

Base Information

Chemical Name:4-(benzyloxy)-6-bromo-3-methyl-2-{[3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl}quinoline
CAS No.:1135036-35-9
Molecular Formula:C₃₀H₃₀BrNO₄
Molecular Weight:548.476
Hs Code.:

Synonyms:4-(benzyloxy)-6-bromo-3-methyl-2-{[3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl}quinoline

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Chemical Property of 4-(benzyloxy)-6-bromo-3-methyl-2-{[3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl}quinoline

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Technology Process of 4-(benzyloxy)-6-bromo-3-methyl-2-{[3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl}quinoline

There total 8 articles about 4-(benzyloxy)-6-bromo-3-methyl-2-{[3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl}quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1135035-14-1
3-(tetrahydro-2H-pyran-4-ylmethoxy)phenol

: 1135033-53-2
C₁₈H₁₅BrClNO

: 1135036-35-9
4-(benzyloxy)-6-bromo-3-methyl-2-{[3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl}quinoline

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃;
DOI:10.1016/j.bmcl.2011.09.015

Reference yield:

: 1135030-91-9
[4-(benzyloxy)-6-bromo-3-methylquinolin-2-yl]methanol

: 1135036-35-9
4-(benzyloxy)-6-bromo-3-methyl-2-{[3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl}quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; thionyl chloride / tetrahydrofuran

2: potassium carbonate / N,N-dimethyl-formamide / 80 °C

With pyridine; thionyl chloride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.09.015

Reference yield:

: 1135030-70-4
ethyl 6-bromo-3-methyl-4-oxo-1,4-dihydroquinoline-2-carboxylate

: 1135036-35-9
4-(benzyloxy)-6-bromo-3-methyl-2-{[3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl}quinoline

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide

2: diisobutylaluminium hydride / toluene / 0 °C

3: sodium tetrahydroborate / tetrahydrofuran; ethanol

4: pyridine; thionyl chloride / tetrahydrofuran

5: potassium carbonate / N,N-dimethyl-formamide / 80 °C

With pyridine; sodium tetrahydroborate; thionyl chloride; diisobutylaluminium hydride; potassium carbonate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2011.09.015