3-methyl-4-oxo-2-{[3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl}-1,4-dihydroquinoline-6-carboxylic acid

Base Information

Chemical Name:3-methyl-4-oxo-2-{[3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl}-1,4-dihydroquinoline-6-carboxylic acid
CAS No.:1135030-67-9
Molecular Formula:C₂₄H₂₅NO₆
Molecular Weight:423.466
Hs Code.:

Synonyms:3-methyl-4-oxo-2-{[3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl}-1,4-dihydroquinoline-6-carboxylic acid

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Chemical Property of 3-methyl-4-oxo-2-{[3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl}-1,4-dihydroquinoline-6-carboxylic acid

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Technology Process of 3-methyl-4-oxo-2-{[3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl}-1,4-dihydroquinoline-6-carboxylic acid

There total 10 articles about 3-methyl-4-oxo-2-{[3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl}-1,4-dihydroquinoline-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1135026-80-0
C₂₆H₂₉NO₆

: 1135030-67-9
3-methyl-4-oxo-2-{[3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl}-1,4-dihydroquinoline-6-carboxylic acid

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; ethanol; at 60 ℃;
DOI:10.1016/j.bmcl.2011.09.015

Reference yield:

: 1135033-53-2
C₁₈H₁₅BrClNO

: 1135030-67-9
3-methyl-4-oxo-2-{[3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl}-1,4-dihydroquinoline-6-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 80 °C

2: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine / dimethyl sulfoxide / 80 °C

3: hydrogenchloride / tetrahydrofuran; ethyl acetate / 60 °C

4: potassium hydroxide / tetrahydrofuran; ethanol / 60 °C

With hydrogenchloride; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; potassium carbonate; triethylamine; potassium hydroxide; In tetrahydrofuran; ethanol; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.09.015

Reference yield:

: 1135030-91-9
[4-(benzyloxy)-6-bromo-3-methylquinolin-2-yl]methanol

: 1135030-67-9
3-methyl-4-oxo-2-{[3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl}-1,4-dihydroquinoline-6-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine; thionyl chloride / tetrahydrofuran

2: potassium carbonate / N,N-dimethyl-formamide / 80 °C

3: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine / dimethyl sulfoxide / 80 °C

4: hydrogenchloride / tetrahydrofuran; ethyl acetate / 60 °C

5: potassium hydroxide / tetrahydrofuran; ethanol / 60 °C

With pyridine; hydrogenchloride; thionyl chloride; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; potassium carbonate; triethylamine; potassium hydroxide; In tetrahydrofuran; ethanol; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.09.015