5-(2-chloro-4-fluorophenyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-1H-pyrrole-3-carboxamide

Base Information

Chemical Name:5-(2-chloro-4-fluorophenyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-1H-pyrrole-3-carboxamide
CAS No.:1221167-07-2
Molecular Formula:C₁₉H₁₆ClFN₂O₃S
Molecular Weight:406.865
Hs Code.:

Synonyms:5-(2-chloro-4-fluorophenyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-1H-pyrrole-3-carboxamide

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Chemical Property of 5-(2-chloro-4-fluorophenyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-1H-pyrrole-3-carboxamide

Chemical Property:

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Technology Process of 5-(2-chloro-4-fluorophenyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-1H-pyrrole-3-carboxamide

There total 5 articles about 5-(2-chloro-4-fluorophenyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-1H-pyrrole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-(2-chloro-4-fluorophenyl)-4-methyl-1H-pyrrole-3-carbonyl chloride

: 177662-76-9
4-(methanesulfonyl)-aniline hydrochloride

: 1221167-07-2
5-(2-chloro-4-fluorophenyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-1H-pyrrole-3-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 20h;

Reference yield:

2-chloro-4-fluorophenylboronic acid: 313545-72-1
2-chloro-4-fluorophenylboronic acid

: 1221167-07-2
5-(2-chloro-4-fluorophenyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 9 h / 110 °C / Inert atmosphere

2: sodium hydroxide / methanol / 4 h / 80 °C

3: oxalyl dichloride / dichloromethane / 2 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 h / 20 °C

With oxalyl dichloride; sodium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; water; toluene; 1: Suzuki Coupling;

Reference yield:

: 881674-29-9
methyl 5-bromo-4-methyl-1H-pyrrole-3-carboxylate

: 1221167-07-2
5-(2-chloro-4-fluorophenyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 9 h / 110 °C / Inert atmosphere

2: sodium hydroxide / methanol / 4 h / 80 °C

3: oxalyl dichloride / dichloromethane / 2 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 h / 20 °C

With oxalyl dichloride; sodium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; water; toluene; 1: Suzuki Coupling;