(S)-N-(4-chloro-3-trifluoromethylphenyl)-4-(3-chloro-5-(1,2-dihydroxyethyl)pyridin-2-yl)piperazine-1-carboxamide

Base Information

Chemical Name:(S)-N-(4-chloro-3-trifluoromethylphenyl)-4-(3-chloro-5-(1,2-dihydroxyethyl)pyridin-2-yl)piperazine-1-carboxamide
CAS No.:1073616-37-1
Molecular Formula:C₁₉H₁₉Cl₂F₃N₄O₃
Molecular Weight:479.286
Hs Code.:

Synonyms:(S)-N-(4-chloro-3-trifluoromethylphenyl)-4-(3-chloro-5-(1,2-dihydroxyethyl)pyridin-2-yl)piperazine-1-carboxamide

Suppliers and Price of (S)-N-(4-chloro-3-trifluoromethylphenyl)-4-(3-chloro-5-(1,2-dihydroxyethyl)pyridin-2-yl)piperazine-1-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-N-(4-chloro-3-trifluoromethylphenyl)-4-(3-chloro-5-(1,2-dihydroxyethyl)pyridin-2-yl)piperazine-1-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-N-(4-chloro-3-trifluoromethylphenyl)-4-(3-chloro-5-(1,2-dihydroxyethyl)pyridin-2-yl)piperazine-1-carboxamide

There total 11 articles about (S)-N-(4-chloro-3-trifluoromethylphenyl)-4-(3-chloro-5-(1,2-dihydroxyethyl)pyridin-2-yl)piperazine-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1073618-18-4
(S)-1-(5-chloro-6-(piperazin-1-yl)pyridin-3-yl)ethane-1,2-diol

: 327-78-6
4-chloro-3-(trifluoromethyl)phenyl isocyanate

: 1073616-37-1
(S)-N-(4-chloro-3-trifluoromethylphenyl)-4-(3-chloro-5-(1,2-dihydroxyethyl)pyridin-2-yl)piperazine-1-carboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 25 ℃; for 4h;

Reference yield:

: 41667-95-2
5,6-dichloronicotinic acid

: 1073616-37-1
(S)-N-(4-chloro-3-trifluoromethylphenyl)-4-(3-chloro-5-(1,2-dihydroxyethyl)pyridin-2-yl)piperazine-1-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 4.5 h / 25 °C

2.1: tetrahydrofuran / 1 h / 0 °C

2.2: 0 °C

3.1: sodium tetrahydroborate / methanol / 0 - 25 °C

4.1: toluene-4-sulfonic acid / chlorobenzene / 140 °C

5.1: sodium t-butanolate / palladium diacetate; 1,3-bis-(diphenylphosphino)propane / toluene / 16 h / 25 - 75 °C

6.1: potassium osmate; potassium carbonate; 1,4-bis(9-O-dihydroquinidine)phthalazine; potassium hexacyanoferrate(III) / water; tert-butyl alcohol / 8 h / 0 °C

7.1: hydrogenchloride / 1,4-dioxane / 1 h / 25 °C

8.1: triethylamine / dichloromethane / 4 h / 0 - 25 °C

With hydrogenchloride; sodium tetrahydroborate; potassium osmate; potassium carbonate; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,4-bis(9-O-dihydroquinidine)phthalazine; triethylamine; sodium t-butanolate; potassium hexacyanoferrate(III); palladium diacetate; 1,3-bis-(diphenylphosphino)propane; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; chlorobenzene; toluene; tert-butyl alcohol;

Reference yield:

: 683243-82-5
(1S,1R)-1-(5,6-dichloro-pyridin-3-yl)-ethanol

: 1073616-37-1
(S)-N-(4-chloro-3-trifluoromethylphenyl)-4-(3-chloro-5-(1,2-dihydroxyethyl)pyridin-2-yl)piperazine-1-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid / chlorobenzene / 140 °C

2: sodium t-butanolate / palladium diacetate; 1,3-bis-(diphenylphosphino)propane / toluene / 16 h / 25 - 75 °C

3: potassium osmate; potassium carbonate; 1,4-bis(9-O-dihydroquinidine)phthalazine; potassium hexacyanoferrate(III) / water; tert-butyl alcohol / 8 h / 0 °C

4: hydrogenchloride / 1,4-dioxane / 1 h / 25 °C

5: triethylamine / dichloromethane / 4 h / 0 - 25 °C

With hydrogenchloride; potassium osmate; potassium carbonate; toluene-4-sulfonic acid; 1,4-bis(9-O-dihydroquinidine)phthalazine; triethylamine; sodium t-butanolate; potassium hexacyanoferrate(III); palladium diacetate; 1,3-bis-(diphenylphosphino)propane; In 1,4-dioxane; dichloromethane; water; chlorobenzene; toluene; tert-butyl alcohol;