5,6-Dichloro-N-methoxy-N-methylpyridine-3-carboxamide

Base Information

• Chemical Name: 5,6-Dichloro-N-methoxy-N-methylpyridine-3-carboxamide
• CAS No.: 162327-73-3
• Molecular Formula: C8H8Cl2N2O2
• Molecular Weight: 235.06732
• Hs Code.: 2933399090
• Mol file: 162327-73-3.mol

Synonyms:5,6-Dichloro-N-methoxy-N-methylpyridine-3-carboxamide

Chemical Property of 5,6-Dichloro-N-methoxy-N-methylpyridine-3-carboxamide

Chemical Property:

• PSA: 42.43000
• LogP: 2.02180

Purity/Quality:

99% ^*data from raw suppliers

5,6-Dichloro-N-methoxy-N-methylpyridine-3-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,6-Dichloro-N-methoxy-N-methylpyridine-3-carboxamide

There total 5 articles about 5,6-Dichloro-N-methoxy-N-methylpyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5,6-dichloronicotinoyl chloride (54127-29-6) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → 5,6-dichloro-N-methoxy-N-methyl-3-pyridinecarboxamide (162327-73-3)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 25 ℃;

Reference yield: 95.3%

5,6-dichloronicotinic acid (41667-95-2) + N,0-dimethylhydroxylamine (1117-97-1) → 5,6-dichloro-N-methoxy-N-methyl-3-pyridinecarboxamide (162327-73-3)

Guidance literature:

5,6-dichloronicotinic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 0 ℃; for 0.5h;

N,0-dimethylhydroxylamine; In dichloromethane; at 20 ℃; for 4h;

Reference yield: 60.0%

Ν,Ο-dimethylhydroxylamine hydrochloride + 5,6-dichloronicotinic acid (41667-95-2) → 5,6-dichloro-N-methoxy-N-methyl-3-pyridinecarboxamide (162327-73-3)

Guidance literature:

5,6-dichloronicotinic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 0 ℃; for 0.5h;

Ν,Ο-dimethylhydroxylamine hydrochloride; In dichloromethane; at 23 ℃; for 17h;

upstream raw materials:

5,6-dichloronicotinoyl chloride

N,O-dimethylhydroxylamine*hydrochloride

5,6-dichloronicotinic acid

N,0-dimethylhydroxylamine

Downstream raw materials:

5,6-dichloro-pyridine-3-carbaldehyde

(S)-N-(4-chloro-3-trifluoromethylphenyl)-4-(3-chloro-5-(1,2-dihydroxyethyl)pyridin-2-yl)piperazine-1-carboxamide

(S)-3-chloro-5-(1,2-dihydroxyethyl)-3',6'-dihydro-2'H-[2,4']bipyridinyl-1'-carboxylic acid (3-chloro-4-trifluoromethylphenyl)amide

(S)-4-(3-chloro-5-(1,2-dihydroxyethyl)pyridin-2-yl)-N-(4-trifluoromethoxyphenyl)piperazine-1-carboxamide