(S)-2-Benzyloxycarbonylamino-6-[2,3-bis-(bis-tert-butoxycarbonylmethyl-amino)-propionylamino]-hexanoic acid 9H-fluoren-9-ylmethyl ester

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Chemical Name:(S)-2-Benzyloxycarbonylamino-6-[2,3-bis-(bis-tert-butoxycarbonylmethyl-amino)-propionylamino]-hexanoic acid 9H-fluoren-9-ylmethyl ester
CAS No.:178802-92-1
Molecular Formula:C₅₅H₇₆N₄O₁₃
Molecular Weight:1001.23
Hs Code.:

Synonyms:(S)-2-Benzyloxycarbonylamino-6-[2,3-bis-(bis-tert-butoxycarbonylmethyl-amino)-propionylamino]-hexanoic acid 9H-fluoren-9-ylmethyl ester

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Chemical Property of (S)-2-Benzyloxycarbonylamino-6-[2,3-bis-(bis-tert-butoxycarbonylmethyl-amino)-propionylamino]-hexanoic acid 9H-fluoren-9-ylmethyl ester

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Technology Process of (S)-2-Benzyloxycarbonylamino-6-[2,3-bis-(bis-tert-butoxycarbonylmethyl-amino)-propionylamino]-hexanoic acid 9H-fluoren-9-ylmethyl ester

There total 2 articles about (S)-2-Benzyloxycarbonylamino-6-[2,3-bis-(bis-tert-butoxycarbonylmethyl-amino)-propionylamino]-hexanoic acid 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24324-17-2
9-Fluorenylmethanol

: 178802-92-1
(S)-2-Benzyloxycarbonylamino-6-[2,3-bis-(bis-tert-butoxycarbonylmethyl-amino)-propionylamino]-hexanoic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / DCC, DMAP / CH₂Cl₂ / Ambient temperature

2: 96 percent / TFA, H₂O / CH₂Cl₂ / 2 h / 0 °C

3: 1.) HOBt, DCC / 1.) DMF, CH₂Cl₂, 0 deg C, 1 h, then rt, 2 h, 2.) diisopropylamine, rt, 4 h

With dmap; water; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;
DOI:10.1080/00397919608004586

Reference yield:

: 145307-15-9
2,3-bispropionic acid

: 178802-91-0
(S)-6-Amino-2-benzyloxycarbonylamino-hexanoic acid 9H-fluoren-9-ylmethyl ester

: 178802-92-1
(S)-2-Benzyloxycarbonylamino-6-[2,3-bis-(bis-tert-butoxycarbonylmethyl-amino)-propionylamino]-hexanoic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; Yield given. Multistep reaction; 1.) DMF, CH₂Cl₂, 0 deg C, 1 h, then rt, 2 h, 2.) diisopropylamine, rt, 4 h;
DOI:10.1080/00397919608004586