(S)-2-Benzyloxycarbonylamino-6-[2,3-bis-(bis-tert-butoxycarbonylmethyl-amino)-propionylamino]-hexanoic acid

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Chemical Name:(S)-2-Benzyloxycarbonylamino-6-[2,3-bis-(bis-tert-butoxycarbonylmethyl-amino)-propionylamino]-hexanoic acid
CAS No.:178802-93-2
Molecular Formula:C₄₁H₆₆N₄O₁₃
Molecular Weight:822.994
Hs Code.:

Synonyms:(S)-2-Benzyloxycarbonylamino-6-[2,3-bis-(bis-tert-butoxycarbonylmethyl-amino)-propionylamino]-hexanoic acid

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Chemical Property of (S)-2-Benzyloxycarbonylamino-6-[2,3-bis-(bis-tert-butoxycarbonylmethyl-amino)-propionylamino]-hexanoic acid

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Technology Process of (S)-2-Benzyloxycarbonylamino-6-[2,3-bis-(bis-tert-butoxycarbonylmethyl-amino)-propionylamino]-hexanoic acid

There total 2 articles about (S)-2-Benzyloxycarbonylamino-6-[2,3-bis-(bis-tert-butoxycarbonylmethyl-amino)-propionylamino]-hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 178802-92-1
(S)-2-Benzyloxycarbonylamino-6-[2,3-bis-(bis-tert-butoxycarbonylmethyl-amino)-propionylamino]-hexanoic acid 9H-fluoren-9-ylmethyl ester

: 178802-93-2
(S)-2-Benzyloxycarbonylamino-6-[2,3-bis-(bis-tert-butoxycarbonylmethyl-amino)-propionylamino]-hexanoic acid

Guidance literature:: With piperidine; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1080/00397919608004586

Reference yield:

: 178802-91-0
(S)-6-Amino-2-benzyloxycarbonylamino-hexanoic acid 9H-fluoren-9-ylmethyl ester

: 178802-93-2
(S)-2-Benzyloxycarbonylamino-6-[2,3-bis-(bis-tert-butoxycarbonylmethyl-amino)-propionylamino]-hexanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) HOBt, DCC / 1.) DMF, CH₂Cl₂, 0 deg C, 1 h, then rt, 2 h, 2.) diisopropylamine, rt, 4 h

2: 76 percent / piperidine / CH₂Cl₂ / 2 h / Ambient temperature

With piperidine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1080/00397919608004586