N-(4-butylphenyl)-3-(4-(2-methoxyphenyl)piperazine-1-carbonyl)-4-morpholinobenzenesulfonamide

Base Information

Chemical Name:N-(4-butylphenyl)-3-(4-(2-methoxyphenyl)piperazine-1-carbonyl)-4-morpholinobenzenesulfonamide
CAS No.:1311382-94-1
Molecular Formula:C₃₂H₄₀N₄O₅S
Molecular Weight:592.759
Hs Code.:

Synonyms:N-(4-butylphenyl)-3-(4-(2-methoxyphenyl)piperazine-1-carbonyl)-4-morpholinobenzenesulfonamide

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Chemical Property of N-(4-butylphenyl)-3-(4-(2-methoxyphenyl)piperazine-1-carbonyl)-4-morpholinobenzenesulfonamide

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Technology Process of N-(4-butylphenyl)-3-(4-(2-methoxyphenyl)piperazine-1-carbonyl)-4-morpholinobenzenesulfonamide

There total 6 articles about N-(4-butylphenyl)-3-(4-(2-methoxyphenyl)piperazine-1-carbonyl)-4-morpholinobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 35386-24-4
1-(2-Methoxyphenyl)piperazine

: 565170-65-2
C₂₁H₂₆N₂O₅S

: 1311382-94-1
N-(4-butylphenyl)-3-(4-(2-methoxyphenyl)piperazine-1-carbonyl)-4-morpholinobenzenesulfonamide

Guidance literature:: C₂₁H₂₆N₂O₅S; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h;

1-(2-Methoxyphenyl)piperazine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: 578-57-4
2-bromoanisole

: 1311382-94-1
N-(4-butylphenyl)-3-(4-(2-methoxyphenyl)piperazine-1-carbonyl)-4-morpholinobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium t-butanolate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 100 °C / Inert atmosphere

2.1: hydrogenchloride / methanol / 2 h

3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.25 h / 0 °C

3.2: 0 - 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In methanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 88-65-3
2-bromobenzoic-acid

: 1311382-94-1
N-(4-butylphenyl)-3-(4-(2-methoxyphenyl)piperazine-1-carbonyl)-4-morpholinobenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: chlorosulfonic acid / 6 h / 0 - 110 °C / Inert atmosphere

2.1: pyridine / dichloromethane / 16 h / 20 °C / Inert atmosphere

3.1: 16 h / 100 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.25 h / 0 °C

4.2: 0 - 20 °C

With pyridine; chlorosulfonic acid; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;