88-65-3 Usage
Description
2-Bromobenzoic acid (2-BA) is a white to light yellow crystal powder that serves as a common building block for the synthesis of various nitrogen heterocycles. It is formed through the condensation with aminoquinolines, yielding phenylquinolylamines.
Uses
Used in Chemical Synthesis:
2-Bromobenzoic acid is used as a starting reagent for the synthesis of hemilabile benzimidazolyl phosphine ligands, which are important in various chemical reactions and applications.
Used in Coordination Chemistry:
2-Bromobenzoic acid is used in the synthesis of new zinc(II) 2-bromobenzoate complex compounds, contributing to the development of coordination chemistry and the study of metal-organic frameworks.
Synthesis Reference(s)
Canadian Journal of Chemistry, 43, p. 1306, 1965 DOI: 10.1139/v65-178The Journal of Organic Chemistry, 59, p. 4042, 1994 DOI: 10.1021/jo00094a007
Purification Methods
Crystallise the acid from *C6H6 or MeOH. The anilide has m 141o (from EtOH/H2O). [Beilstein 9 IV 1011.]
Check Digit Verification of cas no
The CAS Registry Mumber 88-65-3 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 8 and 8 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 88-65:
(4*8)+(3*8)+(2*6)+(1*5)=73
73 % 10 = 3
So 88-65-3 is a valid CAS Registry Number.
InChI:InChI=1/C7H5BrO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,(H,9,10)/p-1
88-65-3Relevant articles and documents
Dewar,M.J.S.,von Rosenberg,J.L.
, p. 358 - 361 (1966)
Aerobic oxidation of aldehydes to carboxylic acids catalyzed by recyclable ag/c3 n4 catalyst
Wu, Chaolong,Yao, Xiaoquan,Yu, Min,Zhou, Li,Zhu, Li
, p. 167 - 175 (2021/03/19)
The oxidation of aldehydes is an efficient methodology for the synthesis of carboxylic acids. Herein we hope to report a simple, efficient and recyclable protocol for aerobic oxidation of aldehydes to carboxylic acid by using C3N4 supported silver nanoparticles (Ag/C3N4) as a catalyst in aqueous solution under mild conditions. Under standard conditions, the corresponding carboxylic acids can be obtained in good to excellent yields. In addition, Ag/C3N4 is convenient for recovery and could be reused three times with satisfactory yields.
Acetyl nitrate mediated conversion of methyl ketones to diverse carboxylic acid derivatives
Bernard, Josephine,Capilato, Joseph N.,Hoy, Erik P.,Mattiucci, Joseph,Pellegrinelli, Peter J.,Perez, Lark J.,Philippi, Shane,Schnorbus, Logan
supporting information, p. 5298 - 5302 (2021/06/30)
The development of a novel acetyl nitrate mediated oxidative conversion of methyl ketones to carboxylic acid derivatives is described. By analogy to the haloform reaction and supported by experimental and computational investigation we propose a mechanism for this transformation.