N-<3-(benzyloxy)-4-methyl-2-nitrobenzoyl>-O-(tert-butoxycarbonyl-N-methyl-L-valyl)-L-threonyl-D-valyl-L-prolylsarcosine ter-butyl ester

Base Information

Chemical Name:N-<3-(benzyloxy)-4-methyl-2-nitrobenzoyl>-O-(tert-butoxycarbonyl-N-methyl-L-valyl)-L-threonyl-D-valyl-L-prolylsarcosine ter-butyl ester
CAS No.:98688-14-3
Molecular Formula:C₄₇H₆₈N₆O₁₃
Molecular Weight:925.089
Hs Code.:

Synonyms:N-<3-(benzyloxy)-4-methyl-2-nitrobenzoyl>-O-(tert-butoxycarbonyl-N-methyl-L-valyl)-L-threonyl-D-valyl-L-prolylsarcosine ter-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-<3-(benzyloxy)-4-methyl-2-nitrobenzoyl>-O-(tert-butoxycarbonyl-N-methyl-L-valyl)-L-threonyl-D-valyl-L-prolylsarcosine ter-butyl ester

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Technology Process of N-<3-(benzyloxy)-4-methyl-2-nitrobenzoyl>-O-(tert-butoxycarbonyl-N-methyl-L-valyl)-L-threonyl-D-valyl-L-prolylsarcosine ter-butyl ester

There total 3 articles about N-<3-(benzyloxy)-4-methyl-2-nitrobenzoyl>-O-(tert-butoxycarbonyl-N-methyl-L-valyl)-L-threonyl-D-valyl-L-prolylsarcosine ter-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 27483-27-8
N-(benzyloxycarbonyl)-D-valylprolylsarcosine tert-butyl ester

: 98688-14-3
N-<3-(benzyloxy)-4-methyl-2-nitrobenzoyl>-O-(tert-butoxycarbonyl-N-methyl-L-valyl)-L-threonyl-D-valyl-L-prolylsarcosine ter-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1,4-cyclohexadiene / 10percent palladium/charcoal / ethanol

2: HONB/DCC / dimethylformamide / 48 h / -5 °C

3: 89 percent / DMAP/DCC / CH₂Cl₂ / 16 h / 26 °C

With dmap; cyclohexa-1,4-diene; dicyclohexyl-carbodiimide; (3aR,4R,7S,7aS)-2-hydroxy-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione (N-hydroxy-5-exo-norbornene-2,3-dicarboximide); palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00310a065

Reference yield:

: 2441-62-5
<3-(benzyloxy)-4-methyl-2-nitro-benzoyl>-L-threonine

: 98688-14-3
N-<3-(benzyloxy)-4-methyl-2-nitrobenzoyl>-O-(tert-butoxycarbonyl-N-methyl-L-valyl)-L-threonyl-D-valyl-L-prolylsarcosine ter-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: HONB/DCC / dimethylformamide / 48 h / -5 °C

2: 89 percent / DMAP/DCC / CH₂Cl₂ / 16 h / 26 °C

With dmap; dicyclohexyl-carbodiimide; (3aR,4R,7S,7aS)-2-hydroxy-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione (N-hydroxy-5-exo-norbornene-2,3-dicarboximide); In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00310a065

Reference yield:

: 5616-83-1
H-D-Val-Pro-Sar-OBu^t

: 98688-14-3
N-<3-(benzyloxy)-4-methyl-2-nitrobenzoyl>-O-(tert-butoxycarbonyl-N-methyl-L-valyl)-L-threonyl-D-valyl-L-prolylsarcosine ter-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: HONB/DCC / dimethylformamide / 48 h / -5 °C

2: 89 percent / DMAP/DCC / CH₂Cl₂ / 16 h / 26 °C

With dmap; dicyclohexyl-carbodiimide; (3aR,4R,7S,7aS)-2-hydroxy-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione (N-hydroxy-5-exo-norbornene-2,3-dicarboximide); In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00310a065