N-((2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)-N-methylacrylamide

Base Information

Chemical Name:N-((2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)-N-methylacrylamide
CAS No.:1276106-24-1
Molecular Formula:C₂₁H₂₂N₄O₃S
Molecular Weight:410.497
Hs Code.:

Synonyms:N-((2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)-N-methylacrylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)-N-methylacrylamide

Chemical Property:

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Technology Process of N-((2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)-N-methylacrylamide

There total 6 articles about N-((2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)-N-methylacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1276186-79-8
3-(6-((methylamino)methyl)-4-morpholinothieno[3,2-d]pyrimidin-2-yl)phenol

: 1276106-24-1
N-((2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)-N-methylacrylamide

Guidance literature:: With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;

Reference yield:

: 955979-15-4
1-(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-N-methylmethanamine

: 1276106-24-1
N-((2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)-N-methylacrylamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethanolamine / dichloromethane

2: water; toluene; hexane; ethanol

3: hydrogenchloride

4: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate

With hydrogenchloride; triethanolamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In ethanol; hexane; dichloromethane; water; toluene;

Reference yield:

: 1276109-56-8
(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl methanesulfonate

: 1276106-24-1
N-((2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)-N-methylacrylamide

Guidance literature:: Multi-step reaction with 5 steps

1: methylamine / tetrahydrofuran

2: triethanolamine / dichloromethane

3: water; toluene; hexane; ethanol

4: hydrogenchloride

5: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate

With hydrogenchloride; triethanolamine; methylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; toluene;