(S)-(-)-tert-butyl 2-(2-(4-methoxyphenyl)-2-oxoethyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(S)-(-)-tert-butyl 2-(2-(4-methoxyphenyl)-2-oxoethyl)pyrrolidine-1-carboxylate
CAS No.:1034128-40-9
Molecular Formula:C₁₈H₂₅NO₄
Molecular Weight:319.401
Hs Code.:

Synonyms:(S)-(-)-tert-butyl 2-(2-(4-methoxyphenyl)-2-oxoethyl)pyrrolidine-1-carboxylate

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Chemical Property of (S)-(-)-tert-butyl 2-(2-(4-methoxyphenyl)-2-oxoethyl)pyrrolidine-1-carboxylate

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Technology Process of (S)-(-)-tert-butyl 2-(2-(4-methoxyphenyl)-2-oxoethyl)pyrrolidine-1-carboxylate

There total 2 articles about (S)-(-)-tert-butyl 2-(2-(4-methoxyphenyl)-2-oxoethyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 104-92-7
1-bromo-4-methoxy-benzene

: 1034128-58-9
(S)-tert-butyl 2-(2-(methoxy(methyl)amino)-2-oxoethyl)pyrrolidine-1-carboxylate

: 1034128-40-9
(S)-(-)-tert-butyl 2-(2-(4-methoxyphenyl)-2-oxoethyl)pyrrolidine-1-carboxylate

Guidance literature:: 1-bromo-4-methoxy-benzene; With magnesium; iodine; In tetrahydrofuran; for 1h; Heating;

(S)-tert-butyl 2-(2-(methoxy(methyl)amino)-2-oxoethyl)pyrrolidine-1-carboxylate; In tetrahydrofuran; at -5 ℃; for 2h; Further stages.;
DOI:10.1016/j.bmc.2008.02.073

Reference yield: 67.0%

: 84766-91-6
tert-butyl 2-hydroxypyrrolidine-1-carboxylate

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 1034128-40-9
(S)-(-)-tert-butyl 2-(2-(4-methoxyphenyl)-2-oxoethyl)pyrrolidine-1-carboxylate

Guidance literature:: With (R)-DTBM-segphos; ClO₄^(1-)*Cu^(1-)*4C₂H₃N; lithium tert-butoxide; In tert-butyl methyl ether; water; at 50 ℃; for 72h; enantioselective reaction; Molecular sieve;
DOI:10.1021/ja308872z DOI:10.1021/ja308872z