2-Chloro-3-(4-fluoro-benzyl)-1-methyl-2-oxo-2,3-dihydro-1H-2λ⁵-benzo[1,3,2]diazaphosphinin-4-one

Base Information

• Chemical Name: 2-Chloro-3-(4-fluoro-benzyl)-1-methyl-2-oxo-2,3-dihydro-1H-2λ⁵-benzo[1,3,2]diazaphosphinin-4-one
• CAS No.: 212266-63-2
• Molecular Formula: C₁₅H₁₃ClFN₂O₂P
• Molecular Weight: 338.706

Synonyms:2-Chloro-3-(4-fluoro-benzyl)-1-methyl-2-oxo-2,3-dihydro-1H-2λ⁵-benzo[1,3,2]diazaphosphinin-4-one

Chemical Property of 2-Chloro-3-(4-fluoro-benzyl)-1-methyl-2-oxo-2,3-dihydro-1H-2λ⁵-benzo[1,3,2]diazaphosphinin-4-one

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Technology Process of 2-Chloro-3-(4-fluoro-benzyl)-1-methyl-2-oxo-2,3-dihydro-1H-2λ⁵-benzo[1,3,2]diazaphosphinin-4-one

There total 2 articles about 2-Chloro-3-(4-fluoro-benzyl)-1-methyl-2-oxo-2,3-dihydro-1H-2λ⁵-benzo[1,3,2]diazaphosphinin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.1%

3-(4-Fluoro-benzyl)-2-methoxy-1-methyl-2,3-dihydro-1H-benzo[1,3,2]diazaphosphinin-4-one (212266-62-1) → 2-Chloro-3-(4-fluoro-benzyl)-1-methyl-2-oxo-2,3-dihydro-1H-2λ5-benzo[1,3,2]diazaphosphinin-4-one (212266-63-2)

Guidance literature:

With sulfuryl dichloride; In dichloromethane; for 18h; Ambient temperature;

DOI:10.1080/10426509708043542

Reference yield:

2-Chloro-3-(4-fluoro-benzyl)-1-methyl-2,3-dihydro-1H-benzo[1,3,2]diazaphosphinin-4-one → 2-Chloro-3-(4-fluoro-benzyl)-1-methyl-2-oxo-2,3-dihydro-1H-2λ5-benzo[1,3,2]diazaphosphinin-4-one (212266-63-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 94.2 percent / CH₂Cl₂ / 7 h

2: 86.1 percent / SO₂Cl₂ / CH₂Cl₂ / 18 h / Ambient temperature

With sulfuryl dichloride; In dichloromethane;

DOI:10.1080/10426509708043542

Reference yield: 36.0%

bis-(2-chloroethyl)amine hydrochloride (821-48-7) + 2-Chloro-3-(4-fluoro-benzyl)-1-methyl-2-oxo-2,3-dihydro-1H-2λ5-benzo[1,3,2]diazaphosphinin-4-one (212266-63-2) → 2-[Bis-(2-chloro-ethyl)-amino]-3-(4-fluoro-benzyl)-1-methyl-2-oxo-2,3-dihydro-1H-2λ5-benzo[1,3,2]diazaphosphinin-4-one

Guidance literature:

With triethylamine; In dichloromethane; for 18h;

DOI:10.1080/10426509708043542

upstream raw materials:

3-(4-Fluoro-benzyl)-2-methoxy-1-methyl-2,3-dihydro-1H-benzo[1,3,2]diazaphosphinin-4-one

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