Thiobenzoic acid S-(4-{1-[(2R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl}-butyl) ester

Base Information

Chemical Name:Thiobenzoic acid S-(4-{1-[(2R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl}-butyl) ester
CAS No.:187245-18-7
Molecular Formula:C₃₂H₅₂N₂O₆SSi₂
Molecular Weight:649.012
Hs Code.:

Thiobenzoic acid S-(4-{1-[(2R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl}-butyl) ester

Synonyms:Thiobenzoic acid S-(4-{1-[(2R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl}-butyl) ester

Suppliers and Price of Thiobenzoic acid S-(4-{1-[(2R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl}-butyl) ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Thiobenzoic acid S-(4-{1-[(2R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl}-butyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Thiobenzoic acid S-(4-{1-[(2R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl}-butyl) ester

There total 6 articles about Thiobenzoic acid S-(4-{1-[(2R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl}-butyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 98-91-9
thiobenzoic acid

: 3',5'-bis-O-(tert-butyldimethylsilyl)-C⁵-(4-methanesulfonylbutyl)-2'-deoxyuridine

: 187245-18-7
Thiobenzoic acid S-(4-{1-[(2R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl}-butyl) ester

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/ja963285h

Reference yield:

: 54-42-2,162239-35-2
5-Iodo-2'-deoxyuridine

: 187245-18-7
Thiobenzoic acid S-(4-{1-[(2R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl}-butyl) ester

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / imidazole / dimethylformamide / 2 h

2: 79 percent / Et₃N, CuI, (Ph₃P)4Pd / dimethylformamide / 18 h

3: 71 percent / H₂ / Pd(C) / methanol / 12 h / Ambient temperature; in the dark

4: 92 percent / Py / CH₂Cl₂ / 0 - 20 °C

5: 92 percent / Et₃N / dimethylformamide

With pyridine; 1H-imidazole; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja963285h

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 187245-18-7
Thiobenzoic acid S-(4-{1-[(2R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl}-butyl) ester

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / imidazole / dimethylformamide / 2 h

2: 79 percent / Et₃N, CuI, (Ph₃P)4Pd / dimethylformamide / 18 h

3: 71 percent / H₂ / Pd(C) / methanol / 12 h / Ambient temperature; in the dark

4: 92 percent / Py / CH₂Cl₂ / 0 - 20 °C

5: 92 percent / Et₃N / dimethylformamide

With pyridine; 1H-imidazole; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja963285h