(2R,4S,5R)-2-(3,4-Dimethoxy-phenyl)-4-phenyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-methyl ester

Base Information

Chemical Name:(2R,4S,5R)-2-(3,4-Dimethoxy-phenyl)-4-phenyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-methyl ester
CAS No.:157580-28-4
Molecular Formula:C₂₄H₂₉NO₇
Molecular Weight:443.497
Hs Code.:

Synonyms:(2R,4S,5R)-2-(3,4-Dimethoxy-phenyl)-4-phenyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-methyl ester

Suppliers and Price of (2R,4S,5R)-2-(3,4-Dimethoxy-phenyl)-4-phenyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,4S,5R)-2-(3,4-Dimethoxy-phenyl)-4-phenyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-methyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2R,4S,5R)-2-(3,4-Dimethoxy-phenyl)-4-phenyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-methyl ester

There total 1 articles about (2R,4S,5R)-2-(3,4-Dimethoxy-phenyl)-4-phenyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 59276-33-4
veratraldehyde dimethyl acetal

: 124605-42-1
methyl (2R,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-3-phenylpropionate

: (2S,4S,5R)-2-(3,4-Dimethoxy-phenyl)-4-phenyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-methyl ester

: 157580-28-4
(2R,4S,5R)-2-(3,4-Dimethoxy-phenyl)-4-phenyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-methyl ester

Guidance literature:: With pyridinium p-toluenesulfonate; In toluene; for 0.5h; Heating;
DOI:10.1016/0040-4039(94)85217-0

Reference yield:

: 157580-28-4
(2R,4S,5R)-2-(3,4-Dimethoxy-phenyl)-4-phenyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-methyl ester

: 114915-20-7,114977-28-5,114977-29-6,133577-32-9,133577-33-0
Docetaxel

Guidance literature:: Multi-step reaction with 4 steps

1: KOH (or LiOH*H₂O) / methanol; H₂O

2: DCC, DMAP / toluene / 1 h / 0 °C

3: CH₃SO₃H / methanol / 2 h / 25 °C

4: 95 percent Chromat_. / Zn, AcOH / ethyl acetate / 3 h / 30 °C

With dmap; methanesulfonic acid; KOH (or LiOH*H₂O); acetic acid; dicyclohexyl-carbodiimide; zinc; In methanol; water; ethyl acetate; toluene;
DOI:10.1016/0040-4039(94)85217-0