2-{2-[2-(2-{2-[2-(2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-3-hydroxy-butyrylamino]-4-methyl-pentanoylamino}-decanoylamino)-5-(2-trimethylsilanyl-ethanesulfonylamino)-pentanoylamino]-3-hydroxy-butyrylamino}-propionic acid benzyl ester

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Chemical Name:2-{2-[2-(2-{2-[2-(2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-3-hydroxy-butyrylamino]-4-methyl-pentanoylamino}-decanoylamino)-5-(2-trimethylsilanyl-ethanesulfonylamino)-pentanoylamino]-3-hydroxy-butyrylamino}-propionic acid benzyl ester
CAS No.:647019-18-9
Molecular Formula:C₅₅H₉₈N₈O₁₄SSi
Molecular Weight:1155.58
Hs Code.:

2-{2-[2-(2-{2-[2-(2-<i>tert</i>-butoxycarbonylamino-4-methyl-pentanoylamino)-3-hydroxy-butyrylamino]-4-methyl-pentanoylamino}-decanoylamino)-5-(2-trimethylsilanyl-ethanesulfonylamino)-pentanoylamino]-3-hydroxy-butyrylamino}-propionic acid benzyl ester

Synonyms:2-{2-[2-(2-{2-[2-(2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-3-hydroxy-butyrylamino]-4-methyl-pentanoylamino}-decanoylamino)-5-(2-trimethylsilanyl-ethanesulfonylamino)-pentanoylamino]-3-hydroxy-butyrylamino}-propionic acid benzyl ester

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Chemical Property of 2-{2-[2-(2-{2-[2-(2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-3-hydroxy-butyrylamino]-4-methyl-pentanoylamino}-decanoylamino)-5-(2-trimethylsilanyl-ethanesulfonylamino)-pentanoylamino]-3-hydroxy-butyrylamino}-propionic acid benzyl ester

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Technology Process of 2-{2-[2-(2-{2-[2-(2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-3-hydroxy-butyrylamino]-4-methyl-pentanoylamino}-decanoylamino)-5-(2-trimethylsilanyl-ethanesulfonylamino)-pentanoylamino]-3-hydroxy-butyrylamino}-propionic acid benzyl ester

There total 18 articles about 2-{2-[2-(2-{2-[2-(2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-3-hydroxy-butyrylamino]-4-methyl-pentanoylamino}-decanoylamino)-5-(2-trimethylsilanyl-ethanesulfonylamino)-pentanoylamino]-3-hydroxy-butyrylamino}-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16937-99-8,53296-34-7
N-Boc-D-Leu

: 647019-18-9
2-{2-[2-(2-{2-[2-(2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-3-hydroxy-butyrylamino]-4-methyl-pentanoylamino}-decanoylamino)-5-(2-trimethylsilanyl-ethanesulfonylamino)-pentanoylamino]-3-hydroxy-butyrylamino}-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / 1-hydroxy-7-azabenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 0 - 25 °C

2: H₂ / Pd/C / ethanol / 1 h / 760 Torr

3: 214 mg / 1-hydroxy-7-azabenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; NaHCO₃ / dimethylformamide / 0 - 25 °C

4: LiOH / tetrahydrofuran; H₂O / 18 h / 0 °C

5: 108 mg / 1-hydroxy-7-azabenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; NaHCO₃ / dimethylformamide / 0 - 25 °C

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; hydrogen; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/ol036083g

Reference yield:

: 142035-62-9
(R)-2-Benzyloxycarbonylamino-decanoic acid methyl ester

: 647019-18-9
2-{2-[2-(2-{2-[2-(2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-3-hydroxy-butyrylamino]-4-methyl-pentanoylamino}-decanoylamino)-5-(2-trimethylsilanyl-ethanesulfonylamino)-pentanoylamino]-3-hydroxy-butyrylamino}-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / H₂ / Pd/C / ethanol / 1 h / 760 Torr

2: 95 percent / 1-hydroxy-7-azabenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 0 - 25 °C

3: HCl / dioxane / 1 h / 25 °C

4: 214 mg / 1-hydroxy-7-azabenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; NaHCO₃ / dimethylformamide / 0 - 25 °C

5: LiOH / tetrahydrofuran; H₂O / 18 h / 0 °C

6: 108 mg / 1-hydroxy-7-azabenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; NaHCO₃ / dimethylformamide / 0 - 25 °C

With hydrogenchloride; lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; hydrogen; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/ol036083g

Reference yield:

: 647019-11-2
Boc-D-Leu-L-Thr-OBn

: 647019-18-9
2-{2-[2-(2-{2-[2-(2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-3-hydroxy-butyrylamino]-4-methyl-pentanoylamino}-decanoylamino)-5-(2-trimethylsilanyl-ethanesulfonylamino)-pentanoylamino]-3-hydroxy-butyrylamino}-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Pd/C / ethanol / 1 h / 760 Torr

2: 214 mg / 1-hydroxy-7-azabenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; NaHCO₃ / dimethylformamide / 0 - 25 °C

3: LiOH / tetrahydrofuran; H₂O / 18 h / 0 °C

4: 108 mg / 1-hydroxy-7-azabenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; NaHCO₃ / dimethylformamide / 0 - 25 °C

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; hydrogen; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/ol036083g