4-bromo-2,6-dimethylbenzyl dimethyl-tert-butylsilyl ether

Base Information

Chemical Name:4-bromo-2,6-dimethylbenzyl dimethyl-tert-butylsilyl ether
CAS No.:127666-66-4
Molecular Formula:C₁₅H₂₅BrOSi
Molecular Weight:329.352
Hs Code.:

Synonyms:4-bromo-2,6-dimethylbenzyl dimethyl-tert-butylsilyl ether

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Chemical Property of 4-bromo-2,6-dimethylbenzyl dimethyl-tert-butylsilyl ether

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Technology Process of 4-bromo-2,6-dimethylbenzyl dimethyl-tert-butylsilyl ether

There total 3 articles about 4-bromo-2,6-dimethylbenzyl dimethyl-tert-butylsilyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 17100-59-3
(4-bromo-2,6-dimethylphenyl)methanol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 127666-66-4
4-bromo-2,6-dimethylbenzyl dimethyl-tert-butylsilyl ether

Guidance literature:: With 1H-imidazole; In dichloromethane; at 0 - 20 ℃;
DOI:10.1002/chem.201903118

Reference yield:

: 5769-33-5
2,6-dimethyl-4-bromobenzaldehyde

: 127666-66-4
4-bromo-2,6-dimethylbenzyl dimethyl-tert-butylsilyl ether

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / LiAlH₄ / tetrahydrofuran / 1 h / 4 °C

2: 85 percent / imidazole / dimethylformamide / 15 h / Ambient temperature

With 1H-imidazole; lithium aluminium tetrahydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo00303a038

Reference yield:

: 5757-66-4
4-bromo-2,6-dimethylbenzonitrile

: 127666-66-4
4-bromo-2,6-dimethylbenzyl dimethyl-tert-butylsilyl ether

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / diisobutylaluminum hydride (DIBAL) / benzene; hexane / 1 h / Ambient temperature

2: 88 percent / LiAlH₄ / tetrahydrofuran / 1 h / 4 °C

3: 85 percent / imidazole / dimethylformamide / 15 h / Ambient temperature

With 1H-imidazole; lithium aluminium tetrahydride; diisobutylaluminium hydride; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo00303a038