3'-chloro-2'-methoxy-5'-methylisonitrosoacetanilide

Base Information

Chemical Name:3'-chloro-2'-methoxy-5'-methylisonitrosoacetanilide
CAS No.:253268-32-5
Molecular Formula:C₁₀H₁₁ClN₂O₃
Molecular Weight:242.662
Hs Code.:

Synonyms:3'-chloro-2'-methoxy-5'-methylisonitrosoacetanilide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3'-chloro-2'-methoxy-5'-methylisonitrosoacetanilide

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Technology Process of 3'-chloro-2'-methoxy-5'-methylisonitrosoacetanilide

There total 1 articles about 3'-chloro-2'-methoxy-5'-methylisonitrosoacetanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 302-17-0
chloral hydrate

: 253268-36-9
3-chloro-2-methoxy-5-methylaniline

: 253268-32-5
3'-chloro-2'-methoxy-5'-methylisonitrosoacetanilide

Guidance literature:: chloral hydrate; 3-chloro-2-methoxy-5-methylaniline; With hydrogenchloride; sodium sulfate; In water; N,N-dimethyl-formamide; at 90 ℃; for 0.416667h;

With hydroxylamine hydrochloride; In water; N,N-dimethyl-formamide; at 90 ℃; for 18h;
DOI:10.1016/S0223-5234(99)00220-2

Reference yield:

: 253268-32-5
3'-chloro-2'-methoxy-5'-methylisonitrosoacetanilide

: 253268-34-7
4-chloro-3-methoxy-6-methylanthranilic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / polyphosphoric acid / 3 h / 80 °C

2: 70 percent / aq. NaOH; 30 percent H₂O₂ / dioxane / 3 h / 5 - 20 °C

With sodium hydroxide; PPA; dihydrogen peroxide; In 1,4-dioxane; 1: Cyclization / 2: Ring cleavage;
DOI:10.1016/S0223-5234(99)00220-2

Reference yield:

: 253268-32-5
3'-chloro-2'-methoxy-5'-methylisonitrosoacetanilide

: 4-chloro-3-hydroxy-6-methylanthranilic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 82 percent / polyphosphoric acid / 3 h / 80 °C

2.1: 70 percent / aq. NaOH; 30 percent H₂O₂ / dioxane / 3 h / 5 - 20 °C

3.1: HCl / diethyl ether

3.2: 47 percent / BBr₃ / CH₂Cl₂ / 43 h / -65 - 20 °C

With hydrogenchloride; sodium hydroxide; PPA; dihydrogen peroxide; In 1,4-dioxane; diethyl ether; 1.1: Cyclization / 2.1: Ring cleavage / 3.1: Addition / 3.2: demethylation;
DOI:10.1016/S0223-5234(99)00220-2