5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2R,5R)-3-methyl-5-phenyl-1,3,2-oxazaphospholidin-2-yl]thymidine

Base Information

• Chemical Name: 5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2R,5R)-3-methyl-5-phenyl-1,3,2-oxazaphospholidin-2-yl]thymidine
• CAS No.: 896723-51-6
• Molecular Formula: C₄₀H₄₂N₃O₈P
• Molecular Weight: 723.763

Synonyms:5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2R,5R)-3-methyl-5-phenyl-1,3,2-oxazaphospholidin-2-yl]thymidine

Chemical Property of 5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2R,5R)-3-methyl-5-phenyl-1,3,2-oxazaphospholidin-2-yl]thymidine

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Technology Process of 5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2R,5R)-3-methyl-5-phenyl-1,3,2-oxazaphospholidin-2-yl]thymidine

There total 2 articles about 5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2R,5R)-3-methyl-5-phenyl-1,3,2-oxazaphospholidin-2-yl]thymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5'-O-(4-4'-dimethoxytrityl)thymidine (40615-39-2) + (5R)-2-chloro-3-methyl-5-phenyl-1,3,2-oxazaphospholidine (573987-69-6) → 5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2R,5R)-3-methyl-5-phenyl-1,3,2-oxazaphospholidin-2-yl]thymidine (896723-51-6)

Guidance literature:

With triethylamine; In tetrahydrofuran; at -78 - 20 ℃; diastereoselective reaction; Inert atmosphere;

DOI:10.1021/ja805780u

Reference yield:

5'-O-(4-4'-dimethoxytrityl)thymidine (40615-39-2) + (5R)-2-chloro-3-methyl-5-phenyl-1,3,2-oxazaphospholidine (573987-69-6) → 5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2S,5R)-3-methyl-5-phenyl-1,3,2-oxazaphospholidin-2-yl]thymidine + 5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2R,5R)-3-methyl-5-phenyl-1,3,2-oxazaphospholidin-2-yl]thymidine (896723-51-6)

Guidance literature:

With triethylamine; In tetrahydrofuran; at -78 - 0 ℃;

DOI:10.1021/ja034502z

Reference yield:

5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2R,5R)-3-methyl-5-phenyl-1,3,2-oxazaphospholidin-2-yl]thymidine (896723-51-6) → 5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2S,5R)-3-methyl-5-phenyl-1,3,2-oxazaphospholidin-2-yl]thymidine

Guidance literature:

With 1-(cyanomethyl)pyrrolidinium trifluoromethanesulfonate; In [D₃]acetonitrile; acetonitrile; at 20 ℃; for 4h;

DOI:10.1021/ja805780u

upstream raw materials:

5'-O-(4-4'-dimethoxytrityl)thymidine

(5R)-2-chloro-3-methyl-5-phenyl-1,3,2-oxazaphospholidine

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