5'-O-(4,4'-Dimethoxytrityl)thymidine

Base Information

Chemical Name:5'-O-(4,4'-Dimethoxytrityl)thymidine
CAS No.:40615-39-2
Deprecated CAS:138799-00-5,169474-07-1,203926-33-4,1093730-81-4,1093730-81-4,169474-07-1,203926-33-4
Molecular Formula:C31H32N2O7
Molecular Weight:544.604
Hs Code.:29349990
European Community (EC) Number:255-003-1
DSSTox Substance ID:DTXSID1074961
Nikkaji Number:J236.252J
Wikidata:Q72468680
ChEMBL ID:CHEMBL3143147
Mol file:40615-39-2.mol

Synonyms:5'-O-dimethoxytritylthymidine;5'-O-dimethyltritylthymidine;5-DMTT

Suppliers and Price of 5'-O-(4,4'-Dimethoxytrityl)thymidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AHH
5'-O-(4,4'-Dimethoxytrityl)thymidine 98%
10g
$ 858.00

AK Scientific
5'-O-(4,4'-Dimethoxytrityl)thymidine
100g
$ 294.00

AK Scientific
5'-O-(4,4'-Dimethoxytrityl)thymidine
1g
$ 10.00

AK Scientific
5'-O-(4,4'-Dimethoxytrityl)thymidine
1g
$ 14.00

AK Scientific
5'-O-(4,4'-Dimethoxytrityl)thymidine
5g
$ 27.00

Alfa Aesar
5'-O-(4,4'-Dimethoxytrityl)thymidine, 98+%
0.1g
$ 45.00

Alfa Aesar
5'-O-(4,4'-Dimethoxytrityl)thymidine, 98+%
0.5g
$ 116.00

Alfa Aesar
5'-O-(4,4'-Dimethoxytrityl)thymidine, 98+%
2g
$ 344.00

Alfa Aesar
5'-O-(4,4'-Dimethoxytrityl)thymidine, 98+%
10g
$ 1236.00

Ambeed
1-((2R,4S,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione 95%
100g
$ 231.00

Total 85 raw suppliers

Chemical Property of 5'-O-(4,4'-Dimethoxytrityl)thymidine

Chemical Property:

Appearance/Colour:White powder
Vapor Pressure:0Pa at 20℃
Melting Point:114-116 °C (subl.)(lit.)
Refractive Index:7 ° (C=1, MeOH)
Boiling Point:618.41°C (rough estimate)
PKA:9.55±0.10(Predicted)
PSA：112.01000
Density:1.272 g/cm³
LogP:3.51930
Storage Temp.:−20°C
Solubility.:Chloroform (Slightly), Methanol (Slightly)
Water Solubility.:3mg/L at 20℃
XLogP3:3.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:9
Exact Mass:544.22095136
Heavy Atom Count:40
Complexity:879

Purity/Quality:

99%, ^*data from raw suppliers

5'-O-(4,4'-Dimethoxytrityl)thymidine 98% ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Chemical Classes:Biological Agents -> Nucleic Acids and Derivatives
Canonical SMILES:CC1=CN(C(=O)NC1=O)C2CC(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O
Isomeric SMILES:CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O
Uses 5'-O-(4,4'-Dimethoxytrityl)thymidine is used in the solid-phase synthesis of polynucleotides and polythymidylic acids by the block coupling phosphotriester method. Further, it is used in the stereoselective synthesis of 3'-deoxy-3'-threo-hydroxymethyl nucleoside. In addition to this, it is used as a research tool for antiviral and anticancer studies.

Technology Process of 5'-O-(4,4'-Dimethoxytrityl)thymidine

There total 63 articles about 5'-O-(4,4'-Dimethoxytrityl)thymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 50-89-5,28854-96-8,3545-96-8,50-88-4
thymidine

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

Guidance literature:: With pyridine; dmap; at 20 ℃; for 5h;
DOI:10.1055/s-2006-933147

Reference yield: 96.0%

: 289712-59-0
2-Azidomethyl-benzoic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

Guidance literature:: With diphenyl(methyl)phosphine; In 1,4-dioxane; water; at 20 ℃; for 0.25h; Further Variations:; Catalysts; Reaction partners; Reagents; Solvents; reaction times; Product distribution;
DOI:10.1016/S0040-4039(00)02183-3