(E)-N-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-(hydroxymethyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamide

Base Information

Chemical Name:(E)-N-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-(hydroxymethyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamide
CAS No.:1363480-78-7
Molecular Formula:C₃₁H₃₉N₃O₈SSi
Molecular Weight:641.817
Hs Code.:

Synonyms:(E)-N-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-(hydroxymethyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamide

Suppliers and Price of (E)-N-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-(hydroxymethyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-N-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-(hydroxymethyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-N-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-(hydroxymethyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamide

There total 13 articles about (E)-N-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-(hydroxymethyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 943-89-5
(E)-3-(4-methoxyphenyl)acrylic acid

: 1363480-72-1
N-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-(hydroxymethyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamide

: 1363480-78-7
(E)-N-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-(hydroxymethyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamide

Guidance literature:: With toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl acetamide; for 4h;
DOI:10.1021/jm201717y

Reference yield:

: 885226-91-5
1-(1-(chloromethyl)-1H-benzo[e]indol-3(2H)-yl)-2,2,2-trifluoroethanone

: 1363480-78-7
(E)-N-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-(hydroxymethyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1: sodium iodide / butanone / 17 h / 85 °C

2: 18-crown-6 ether / acetic acid / 120 h / 100 °C

3: chlorosulfonic acid / dichloromethane / -80 - 5 °C

4: oxalyl dichloride / N,N-dimethyl-formamide / 3 h / -10 - 5 °C

5: sulfuric acid; potassium nitrate / 0.25 h / -12 °C

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / 0 °C

7: water; caesium carbonate / methanol / 2.5 h / 0 - 20 °C

8: toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl acetamide / 4 h

With chlorosulfonic acid; oxalyl dichloride; 18-crown-6 ether; sulfuric acid; water; caesium carbonate; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium nitrate; N-ethyl-N,N-diisopropylamine; sodium iodide; In methanol; dichloromethane; N,N-dimethyl acetamide; acetic acid; N,N-dimethyl-formamide; butanone;
DOI:10.1021/jm201717y

Reference yield:

: 1214876-51-3
2,2,2-trifluoro-1-(1-(iodomethyl)-1,2-dihydro-3H-benzo[e]indol-3-yl)ethan-1-one

: 1363480-78-7
(E)-N-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-(hydroxymethyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1: 18-crown-6 ether / acetic acid / 120 h / 100 °C

2: chlorosulfonic acid / dichloromethane / -80 - 5 °C

3: oxalyl dichloride / N,N-dimethyl-formamide / 3 h / -10 - 5 °C

4: sulfuric acid; potassium nitrate / 0.25 h / -12 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / 0 °C

6: water; caesium carbonate / methanol / 2.5 h / 0 - 20 °C

7: toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl acetamide / 4 h

With chlorosulfonic acid; oxalyl dichloride; 18-crown-6 ether; sulfuric acid; water; caesium carbonate; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium nitrate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl acetamide; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm201717y