tert-butyl (2S)-2-{5-[4-(5-{2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1H-benzimidazol-5-yl}prazin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (2S)-2-{5-[4-(5-{2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1H-benzimidazol-5-yl}prazin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carboxylate
CAS No.:1352212-37-3
Molecular Formula:C₃₈H₄₄N₈O₄
Molecular Weight:676.819
Hs Code.:

tert-butyl (2S)-2-{5-[4-(5-{2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1H-benzimidazol-5-yl}prazin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carboxylate

Synonyms:tert-butyl (2S)-2-{5-[4-(5-{2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1H-benzimidazol-5-yl}prazin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carboxylate

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Chemical Property of tert-butyl (2S)-2-{5-[4-(5-{2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1H-benzimidazol-5-yl}prazin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carboxylate

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Technology Process of tert-butyl (2S)-2-{5-[4-(5-{2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1H-benzimidazol-5-yl}prazin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carboxylate

There total 17 articles about tert-butyl (2S)-2-{5-[4-(5-{2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1H-benzimidazol-5-yl}prazin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1007882-12-3
(S)-2-{4-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-1H-imidazol-2-yl}-pyrrolidine-1-carboxylic acid tert-butyl ester

: 1352212-36-2
tert-butyl (2S)-2-[5-(5-bromopyrazin-2-yl)-1H-benzimidazol-2-yl]pyrrolidine-1-carboxylate

: 1352212-37-3
C₃₈H₄₄N₈O₄

Guidance literature:: With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; at 100 ℃;
DOI:10.1002/cmdc.201400045

Reference yield:

: 1208009-37-3
(S)-tert-butyl 2-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazol-2-yl)pyrrolidine-1-carboxylate

: 1352212-71-5
tert-butyl (2S)-2-{4-[4-(5-bromopyrazin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carboxylate

: 1352212-37-3
tert-butyl (2S)-2-{5-[4-(5-{2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1H-benzimidazol-5-yl}prazin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carboxylate

Guidance literature:: With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; for 3h; Inert atmosphere; Reflux;

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 1352212-37-3
tert-butyl (2S)-2-{5-[4-(5-{2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1H-benzimidazol-5-yl}prazin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2.5 h / 0 - 20 °C

2: ammonium acetate / xylenes / 5 h / 150 °C

3: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 2 h / Inert atmosphere; Reflux

4: potassium phosphate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 16 h / 120 °C

With potassium phosphate; ammonium acetate; potassium acetate; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; dichloromethane; water; xylenes;