1-(4-(pyridin-2-yl)-phenyl)-1-oxo-5(S)-2,5-di[(tert-butoxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

Base Information

Chemical Name:1-(4-(pyridin-2-yl)-phenyl)-1-oxo-5(S)-2,5-di[(tert-butoxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
CAS No.:198905-10-1
Molecular Formula:C₃₂H₄₀N₄O₆
Molecular Weight:576.693
Hs Code.:

Synonyms:1-(4-(pyridin-2-yl)-phenyl)-1-oxo-5(S)-2,5-di[(tert-butoxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

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Chemical Property of 1-(4-(pyridin-2-yl)-phenyl)-1-oxo-5(S)-2,5-di[(tert-butoxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-(4-(pyridin-2-yl)-phenyl)-1-oxo-5(S)-2,5-di[(tert-butoxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

There total 6 articles about 1-(4-(pyridin-2-yl)-phenyl)-1-oxo-5(S)-2,5-di[(tert-butoxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 870-46-2
t-butoxycarbonylhydrazine

: 198905-10-1
1-(4-(pyridin-2-yl)-phenyl)-1-oxo-5(S)-2,5-di[(tert-butoxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

Guidance literature:: Multi-step reaction with 3 steps

1: 53 percent / H₂, AcOH / Raney Ni / methanol / 750.06 Torr / Ambient temperature

2: NaBH₃CN, TsOH / 1,2-dimethoxy-ethane / Ambient temperature

3: 1.) aq. borax; 2.) MTBD

With borax; hydrogen; sodium cyanoborohydride; toluene-4-sulfonic acid; acetic acid; 1-methyl-2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidine; nickel; In methanol; 1,2-dimethoxyethane;
DOI:10.1016/S0040-4039(98)00897-1

Reference yield:

: 72155-45-4
Boc-L-phenylalaninal

: 198905-10-1
1-(4-(pyridin-2-yl)-phenyl)-1-oxo-5(S)-2,5-di[(tert-butoxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

Guidance literature:: Multi-step reaction with 4 steps

1: 39 percent / BnEt₃N⁽¹⁺⁾*Cl^(1-) / H₂O; CH₂Cl₂ / 0 °C

2: 53 percent / H₂, AcOH / Raney Ni / methanol / 750.06 Torr / Ambient temperature

3: NaBH₃CN, TsOH / 1,2-dimethoxy-ethane / Ambient temperature

4: 1.) aq. borax; 2.) MTBD

With borax; N-benzyl-N,N,N-triethylammonium chloride; hydrogen; sodium cyanoborohydride; toluene-4-sulfonic acid; acetic acid; 1-methyl-2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidine; nickel; In methanol; 1,2-dimethoxyethane; dichloromethane; water;
DOI:10.1016/S0040-4039(98)00897-1

Reference yield:

: 198905-08-7
4-Pyridin-2-yl-benzoic acid (1R,2S)-2-tert-butoxycarbonylamino-1-cyano-3-phenyl-propyl ester

: 198905-10-1
1-(4-(pyridin-2-yl)-phenyl)-1-oxo-5(S)-2,5-di[(tert-butoxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

Guidance literature:: Multi-step reaction with 3 steps

1: 53 percent / H₂, AcOH / Raney Ni / methanol / 750.06 Torr / Ambient temperature

2: NaBH₃CN, TsOH / 1,2-dimethoxy-ethane / Ambient temperature

3: 1.) aq. borax; 2.) MTBD

With borax; hydrogen; sodium cyanoborohydride; toluene-4-sulfonic acid; acetic acid; 1-methyl-2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidine; nickel; In methanol; 1,2-dimethoxyethane;
DOI:10.1016/S0040-4039(98)00897-1