12-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoic acid pentafluorophenyl ester

Base Information

• Chemical Name: 12-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoic acid pentafluorophenyl ester
• CAS No.: 178960-98-0
• Molecular Formula: C₃₉H₄₁F₅O₅
• Molecular Weight: 684.744
• Mol file: 178960-98-0.mol

Synonyms:12-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoic acid pentafluorophenyl ester

Chemical Property of 12-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoic acid pentafluorophenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 12-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoic acid pentafluorophenyl ester

There total 1 articles about 12-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoic acid pentafluorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

12-hydroxydodecanoic acid (505-95-3) + 2,3,4,5,6-pentafluorophenol (771-61-9) + 4,4'-dimethoxytrityl chloride (40615-36-9) → 12-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoic acid pentafluorophenyl ester (178960-98-0)

Guidance literature:

With pyridine; dicyclohexyl-carbodiimide; Yield given. Multistep reaction; 1) 0 deg C, 1 h 20 min; room temperature, 24 h, 2) CH₂Cl₂, 0 deg C, 5 h, room temperature, overnight;

DOI:10.1080/00397919608004566

Reference yield: 100.0%

1,3-Diamino-2-hydroxypropane (616-29-5) + 12-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoic acid pentafluorophenyl ester (178960-98-0) → 12-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoic acid (3-{12-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoylamino}-2-hydroxy-propyl)-amide (178961-00-7)

Guidance literature:

With pyridine; In tetrahydrofuran; for 6h;

DOI:10.1080/00397919608004566

Reference yield:

12-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoic acid pentafluorophenyl ester (178960-98-0) → Diisopropyl-phosphoramidous acid 2-{12-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoylamino}-1-({12-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoylamino}-methyl)-ethyl ester 2-cyano-ethyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / pyridine / tetrahydrofuran / 6 h

2: 57 percent / diisopropylammonium tetrazolide / acetonitrile; CH₂Cl₂ / 2.75 h

With pyridine; N,N-diisopropylamine tetrazolide; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1080/00397919608004566

upstream raw materials:

12-hydroxydodecanoic acid

2,3,4,5,6-pentafluorophenol

4,4'-dimethoxytrityl chloride

Downstream raw materials:

12-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoic acid (3-{12-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoylamino}-2-hydroxy-propyl)-amide