12-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoic acid (3-{12-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoylamino}-2-hydroxy-propyl)-amide

Base Information

• Chemical Name: 12-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoic acid (3-{12-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoylamino}-2-hydroxy-propyl)-amide
• CAS No.: 178961-00-7
• Molecular Formula: C₆₉H₉₀N₂O₉
• Molecular Weight: 1091.48
• Mol file: 178961-00-7.mol

Synonyms:12-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoic acid (3-{12-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoylamino}-2-hydroxy-propyl)-amide

Chemical Property of 12-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoic acid (3-{12-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoylamino}-2-hydroxy-propyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 12-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoic acid (3-{12-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoylamino}-2-hydroxy-propyl)-amide

There total 2 articles about 12-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoic acid (3-{12-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoylamino}-2-hydroxy-propyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1,3-Diamino-2-hydroxypropane (616-29-5) + 12-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoic acid pentafluorophenyl ester (178960-98-0) → 12-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoic acid (3-{12-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoylamino}-2-hydroxy-propyl)-amide (178961-00-7)

Guidance literature:

With pyridine; In tetrahydrofuran; for 6h;

DOI:10.1080/00397919608004566

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → 12-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoic acid (3-{12-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoylamino}-2-hydroxy-propyl)-amide (178961-00-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) pyridine, 2) dicyclohexylcarbodiimide, pyridine / 1) 0 deg C, 1 h 20 min; room temperature, 24 h, 2) CH₂Cl₂, 0 deg C, 5 h, room temperature, overnight

2: 100 percent / pyridine / tetrahydrofuran / 6 h

With pyridine; dicyclohexyl-carbodiimide; In tetrahydrofuran;

DOI:10.1080/00397919608004566

Reference yield: 57.0%

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite (102691-36-1) + 12-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoic acid (3-{12-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoylamino}-2-hydroxy-propyl)-amide (178961-00-7) → Diisopropyl-phosphoramidous acid 2-{12-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoylamino}-1-({12-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoylamino}-methyl)-ethyl ester 2-cyano-ethyl ester

Guidance literature:

With N,N-diisopropylamine tetrazolide; In dichloromethane; acetonitrile; for 2.75h;

DOI:10.1080/00397919608004566

upstream raw materials:

1,3-Diamino-2-hydroxypropane

12-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoic acid pentafluorophenyl ester

4,4'-dimethoxytrityl chloride