(2S)-N-(tert-butyloxycarbonyl)piperidin-2-yl 4-bromophenyl ketone

Base Information

• Chemical Name: (2S)-N-(tert-butyloxycarbonyl)piperidin-2-yl 4-bromophenyl ketone
• CAS No.: 203056-29-5
• Molecular Formula: C₁₇H₂₂BrNO₃
• Molecular Weight: 368.271
• Mol file: 203056-29-5.mol

Synonyms:(2S)-N-(tert-butyloxycarbonyl)piperidin-2-yl 4-bromophenyl ketone

Chemical Property of (2S)-N-(tert-butyloxycarbonyl)piperidin-2-yl 4-bromophenyl ketone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-N-(tert-butyloxycarbonyl)piperidin-2-yl 4-bromophenyl ketone

There total 4 articles about (2S)-N-(tert-butyloxycarbonyl)piperidin-2-yl 4-bromophenyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

4-bromophenyllithium (22480-64-4) + tert-butyl (2S)-2-{[methoxy(methyl)amino]-carbonyl}piperidine-1-carboxylate (203056-27-3) → (2S)-N-(tert-butyloxycarbonyl)piperidin-2-yl 4-bromophenyl ketone (203056-29-5)

Guidance literature:

In diethyl ether; hexane; at -23 ℃; for 3h;

DOI:10.1021/jm970620j

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → (2S)-N-(tert-butyloxycarbonyl)piperidin-2-yl 4-bromophenyl ketone (203056-29-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / TEA / methanol / a) 50 deg C, 5 min, b) RT, 1 h

2: 94 percent / TEA, BOP / CH₂Cl₂ / 6 h

3: 28 percent / diethyl ether; hexane / 3 h / -23 °C

With TEA; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In methanol; diethyl ether; hexane; dichloromethane;

DOI:10.1021/jm970620j

Reference yield:

(S)-(-)-1-(tert-butoxycarbonyl)-2-piperidinecarboxylic acid (26250-84-0) → (2S)-N-(tert-butyloxycarbonyl)piperidin-2-yl 4-bromophenyl ketone (203056-29-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / TEA, BOP / CH₂Cl₂ / 6 h

2: 28 percent / diethyl ether; hexane / 3 h / -23 °C

With TEA; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In diethyl ether; hexane; dichloromethane;

DOI:10.1021/jm970620j

upstream raw materials:

4-bromophenyllithium

tert-butyl (2S)-2-{[methoxy(methyl)amino]-carbonyl}piperidine-1-carboxylate

di-tert-butyl dicarbonate

(S)-(-)-1-(tert-butoxycarbonyl)-2-piperidinecarboxylic acid