α,α-bis(4-fluorophenyl)-1-(phenylmethyl)-3-pyrrolidinemethanol

Base Information

• Chemical Name: α,α-bis(4-fluorophenyl)-1-(phenylmethyl)-3-pyrrolidinemethanol
• CAS No.: 117022-72-7
• Molecular Formula: C₂₄H₂₃F₂NO
• Molecular Weight: 379.45
• Mol file: 117022-72-7.mol

Synonyms:α,α-bis(4-fluorophenyl)-1-(phenylmethyl)-3-pyrrolidinemethanol

Chemical Property of α,α-bis(4-fluorophenyl)-1-(phenylmethyl)-3-pyrrolidinemethanol

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of α,α-bis(4-fluorophenyl)-1-(phenylmethyl)-3-pyrrolidinemethanol

There total 4 articles about α,α-bis(4-fluorophenyl)-1-(phenylmethyl)-3-pyrrolidinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

4--1-(phenylmethyl)-2-pyrrolidinone (117022-79-4) → α,α-bis(4-fluorophenyl)-1-(phenylmethyl)-3-pyrrolidinemethanol (117022-72-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Heating;

DOI:10.1021/jm00121a022

Reference yield:

methyl 1-benzyl-5-oxo-3-pyrrolidinecarboxylate (51535-00-3) → α,α-bis(4-fluorophenyl)-1-(phenylmethyl)-3-pyrrolidinemethanol (117022-72-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) Mg / 1) THF, reflux, 15 min; 2) THF, room temperature, overnight

2: 81 percent / LiAlH₄ / tetrahydrofuran / 2 h / Heating

With lithium aluminium tetrahydride; magnesium; In tetrahydrofuran;

DOI:10.1021/jm00121a022

Reference yield:

1-Bromo-4-fluorobenzene (460-00-4) → α,α-bis(4-fluorophenyl)-1-(phenylmethyl)-3-pyrrolidinemethanol (117022-72-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) Mg / 1) THF, reflux, 15 min; 2) THF, room temperature, overnight

2: 81 percent / LiAlH₄ / tetrahydrofuran / 2 h / Heating

With lithium aluminium tetrahydride; magnesium; In tetrahydrofuran;

DOI:10.1021/jm00121a022

upstream raw materials:

4--1-(phenylmethyl)-2-pyrrolidinone

methyl 1-benzyl-5-oxo-3-pyrrolidinecarboxylate

1-Bromo-4-fluorobenzene

Downstream raw materials:

1-[4-[3-[3-[bis(4-fluorophenyl)hydroxymethyl]-1-pyrrolidinyl]propoxy]-3-methoxyphenyl]ethanone

α,α-bis(4-fluorophenyl)-3-pyrrolidinemethanol