methyl (S)-1-(2-(biphenyl-4-ylmethyl)-2-((2S,3S)-2-hydroxy-3-((1R,3S)-3-(methoxycarbonylamino)-2,2-dimethylcyclobutanecarboxamido)-4-phenylbutyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate

Base Information

Chemical Name:methyl (S)-1-(2-(biphenyl-4-ylmethyl)-2-((2S,3S)-2-hydroxy-3-((1R,3S)-3-(methoxycarbonylamino)-2,2-dimethylcyclobutanecarboxamido)-4-phenylbutyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate
CAS No.:1313358-38-1
Molecular Formula:C₄₀H₅₃N₅O₇
Molecular Weight:715.89
Hs Code.:

methyl (S)-1-(2-(biphenyl-4-ylmethyl)-2-((2S,3S)-2-hydroxy-3-((1R,3S)-3-(methoxycarbonylamino)-2,2-dimethylcyclobutanecarboxamido)-4-phenylbutyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate

Synonyms:methyl (S)-1-(2-(biphenyl-4-ylmethyl)-2-((2S,3S)-2-hydroxy-3-((1R,3S)-3-(methoxycarbonylamino)-2,2-dimethylcyclobutanecarboxamido)-4-phenylbutyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate

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Chemical Property of methyl (S)-1-(2-(biphenyl-4-ylmethyl)-2-((2S,3S)-2-hydroxy-3-((1R,3S)-3-(methoxycarbonylamino)-2,2-dimethylcyclobutanecarboxamido)-4-phenylbutyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate

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Technology Process of methyl (S)-1-(2-(biphenyl-4-ylmethyl)-2-((2S,3S)-2-hydroxy-3-((1R,3S)-3-(methoxycarbonylamino)-2,2-dimethylcyclobutanecarboxamido)-4-phenylbutyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate

There total 19 articles about methyl (S)-1-(2-(biphenyl-4-ylmethyl)-2-((2S,3S)-2-hydroxy-3-((1R,3S)-3-(methoxycarbonylamino)-2,2-dimethylcyclobutanecarboxamido)-4-phenylbutyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1313358-77-8
(1R,3S)-3-(methoxycarbonylamino)-2,2-dimethylcyclobutanecarboxylic acid

: 1313358-79-0
methyl (S)-1-(2-((2S,3S)-3-amino-2-hydroxy-4-phenylbutyl)-2-(biphenyl-4-ylmethyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate

: 1313358-38-1
methyl (S)-1-(2-(biphenyl-4-ylmethyl)-2-((2S,3S)-2-hydroxy-3-((1R,3S)-3-(methoxycarbonylamino)-2,2-dimethylcyclobutanecarboxamido)-4-phenylbutyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate

Guidance literature:: (1R,3S)-3-(methoxycarbonylamino)-2,2-dimethylcyclobutanecarboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃;

methyl (S)-1-(2-((2S,3S)-3-amino-2-hydroxy-4-phenylbutyl)-2-(biphenyl-4-ylmethyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate; With 4-methyl-morpholine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

: 3218-36-8
4-Phenylbenzaldehyde

: 1313358-38-1
methyl (S)-1-(2-(biphenyl-4-ylmethyl)-2-((2S,3S)-2-hydroxy-3-((1R,3S)-3-(methoxycarbonylamino)-2,2-dimethylcyclobutanecarboxamido)-4-phenylbutyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: isopropyl alcohol / 16 h / Reflux

2.1: hydrogen; sodium formate / palladium 10% on activated carbon / ethanol; water / 2 h / 20 °C

3.1: isopropyl alcohol / 16 h / Reflux

4.1: hydrogenchloride; water / tetrahydrofuran / 2 h / 0 - 50 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0 °C

5.2: 24 h / 20 °C

With hydrogenchloride; water; hydrogen; sodium formate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; isopropyl alcohol;

Reference yield:

: 1122-91-4
4-bromo-benzaldehyde

: 1313358-38-1
methyl (S)-1-(2-(biphenyl-4-ylmethyl)-2-((2S,3S)-2-hydroxy-3-((1R,3S)-3-(methoxycarbonylamino)-2,2-dimethylcyclobutanecarboxamido)-4-phenylbutyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol / 3 h / 70 °C / Inert atmosphere

2.1: isopropyl alcohol / 16 h / Reflux

3.1: hydrogen; sodium formate / palladium 10% on activated carbon / ethanol; water / 2 h / 20 °C

4.1: isopropyl alcohol / 16 h / Reflux

5.1: hydrogenchloride; water / tetrahydrofuran / 2 h / 0 - 50 °C

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0 °C

6.2: 24 h / 20 °C

With hydrogenchloride; water; hydrogen; sodium formate; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; isopropyl alcohol; toluene;