(S)-3-[(R)-1-(4-chloro-2-fluoro-3-phenoxy-phenyl)-propylamino]-butyramide

Base Information

Chemical Name:(S)-3-[(R)-1-(4-chloro-2-fluoro-3-phenoxy-phenyl)-propylamino]-butyramide
CAS No.:1401839-27-7
Molecular Formula:C₁₉H₂₂ClFN₂O₂
Molecular Weight:364.847
Hs Code.:

Synonyms:(S)-3-[(R)-1-(4-chloro-2-fluoro-3-phenoxy-phenyl)-propylamino]-butyramide

Suppliers and Price of (S)-3-[(R)-1-(4-chloro-2-fluoro-3-phenoxy-phenyl)-propylamino]-butyramide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of (S)-3-[(R)-1-(4-chloro-2-fluoro-3-phenoxy-phenyl)-propylamino]-butyramide

Chemical Property:

Boiling Point:476.4±45.0 °C(Predicted)
Density:1?+-.0.06 g/cm3(Predicted)

Purity/Quality:: ≥95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of (S)-3-[(R)-1-(4-chloro-2-fluoro-3-phenoxy-phenyl)-propylamino]-butyramide

There total 8 articles about (S)-3-[(R)-1-(4-chloro-2-fluoro-3-phenoxy-phenyl)-propylamino]-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5977-14-0
acetoacetamido

: 1434725-41-3
(R)-1-(4-chloro-2-fluoro-3-phenoxy-phenyl)-propylamine hydrochloride

: 1401839-27-7
(S)-3-[(R)-1-(4-chloro-2-fluoro-3-phenoxy-phenyl)-propylamino]-butyramide

: 1401839-48-2
(R)-3-[(R)-1-(4-chloro-2-fluoro-3-phenoxy-phenyl)-propylamino]-butyramide

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; triethylamine; In 1,2-dichloro-ethane; at 20 ℃; for 24h;

Reference yield:

: 2-trimethylsilyloxyphenyl triflate

: 1401839-27-7
(S)-3-[(R)-1-(4-chloro-2-fluoro-3-phenoxy-phenyl)-propylamino]-butyramide

: 1401839-48-2
(R)-3-[(R)-1-(4-chloro-2-fluoro-3-phenoxy-phenyl)-propylamino]-butyramide

Guidance literature:: Multi-step reaction with 7 steps

1: cesium fluoride / acetonitrile / 20 °C / Inert atmosphere

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 80 °C / Inert atmosphere

3: silver nitrate / isopropyl alcohol; water / 2 h

4: titanium(IV) tetraethanolate / dichloromethane / Inert atmosphere

5: tetrahydrofuran / 3 h / -70 °C

6: hydrogenchloride / methanol; 1,4-dioxane / 1 h

7: sodium tris(acetoxy)borohydride; acetic acid; triethylamine / 1,2-dichloro-ethane / 24 h / 20 °C

With hydrogenchloride; titanium(IV) tetraethanolate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium tris(acetoxy)borohydride; silver nitrate; acetic acid; triethylamine; cesium fluoride; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; dichloromethane; water; 1,2-dichloro-ethane; isopropyl alcohol; acetonitrile;

Reference yield:

: 765302-73-6
1-chloro-3-fluoro-4-methyl-2-phenoxybenzene

: 1401839-27-7
(S)-3-[(R)-1-(4-chloro-2-fluoro-3-phenoxy-phenyl)-propylamino]-butyramide

: 1401839-48-2
(R)-3-[(R)-1-(4-chloro-2-fluoro-3-phenoxy-phenyl)-propylamino]-butyramide

Guidance literature:: Multi-step reaction with 6 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 80 °C / Inert atmosphere

2: silver nitrate / isopropyl alcohol; water / 2 h

3: titanium(IV) tetraethanolate / dichloromethane / Inert atmosphere

4: tetrahydrofuran / 3 h / -70 °C

5: hydrogenchloride / methanol; 1,4-dioxane / 1 h

6: sodium tris(acetoxy)borohydride; acetic acid; triethylamine / 1,2-dichloro-ethane / 24 h / 20 °C

With hydrogenchloride; titanium(IV) tetraethanolate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium tris(acetoxy)borohydride; silver nitrate; acetic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; dichloromethane; water; 1,2-dichloro-ethane; isopropyl alcohol;