(R)-1-(4-chloro-2-fluoro-3-phenoxy-phenyl)-propylamine hydrochloride

Base Information

Chemical Name:(R)-1-(4-chloro-2-fluoro-3-phenoxy-phenyl)-propylamine hydrochloride
CAS No.:1434725-41-3
Molecular Formula:C₁₅H₁₅ClFNO*ClH
Molecular Weight:316.203
Hs Code.:

Synonyms:(R)-1-(4-chloro-2-fluoro-3-phenoxy-phenyl)-propylamine hydrochloride

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Chemical Property of (R)-1-(4-chloro-2-fluoro-3-phenoxy-phenyl)-propylamine hydrochloride

Chemical Property:

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Technology Process of (R)-1-(4-chloro-2-fluoro-3-phenoxy-phenyl)-propylamine hydrochloride

There total 7 articles about (R)-1-(4-chloro-2-fluoro-3-phenoxy-phenyl)-propylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-trimethylsilyloxyphenyl triflate

: 1434725-41-3
(R)-1-(4-chloro-2-fluoro-3-phenoxy-phenyl)-propylamine hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: cesium fluoride / acetonitrile / 20 °C / Inert atmosphere

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 80 °C / Inert atmosphere

3: silver nitrate / isopropyl alcohol; water / 2 h

4: titanium(IV) tetraethanolate / dichloromethane / Inert atmosphere

5: tetrahydrofuran / 3 h / -70 °C

6: hydrogenchloride / methanol; 1,4-dioxane / 1 h

With hydrogenchloride; titanium(IV) tetraethanolate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); silver nitrate; cesium fluoride; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; dichloromethane; water; isopropyl alcohol; acetonitrile;

Reference yield:

: 1401839-38-0
1-chloro-4-dibromomethyl-3-fluoro-2-phenoxybenzene

: 1434725-41-3
(R)-1-(4-chloro-2-fluoro-3-phenoxy-phenyl)-propylamine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: silver nitrate / isopropyl alcohol; water / 2 h

2: titanium(IV) tetraethanolate / dichloromethane / Inert atmosphere

3: tetrahydrofuran / 3 h / -70 °C

4: hydrogenchloride / methanol; 1,4-dioxane / 1 h

With hydrogenchloride; titanium(IV) tetraethanolate; silver nitrate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; isopropyl alcohol;

Reference yield:

: 1401839-40-4
4-chloro-2-fluoro-3-phenoxybenzaldehyde

: 1434725-41-3
(R)-1-(4-chloro-2-fluoro-3-phenoxy-phenyl)-propylamine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: titanium(IV) tetraethanolate / dichloromethane / Inert atmosphere

2: tetrahydrofuran / 3 h / -70 °C

3: hydrogenchloride / methanol; 1,4-dioxane / 1 h

With hydrogenchloride; titanium(IV) tetraethanolate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;