Methyl 3'-chloro-2'-formyl-5'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylate

Base Information

Chemical Name:Methyl 3'-chloro-2'-formyl-5'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylate
CAS No.:1414931-76-2
Molecular Formula:C₁₆H₁₀ClF₃O₃
Molecular Weight:342.702
Hs Code.:

Synonyms:Methyl 3'-chloro-2'-formyl-5'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylate

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Chemical Property of Methyl 3'-chloro-2'-formyl-5'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylate

Chemical Property:

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Technology Process of Methyl 3'-chloro-2'-formyl-5'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylate

There total 1 articles about Methyl 3'-chloro-2'-formyl-5'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 118754-52-2
2,6-dichloro-4-(trifluoromethyl)benzaldehyde

: 99768-12-4
4-methoxycarbonylphenylboronic acid

: 1414931-76-2
Methyl 3'-chloro-2'-formyl-5'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylate

Guidance literature:: With potassium phosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; at 90 ℃; for 10h;

Reference yield:

: 1414931-76-2
Methyl 3'-chloro-2'-formyl-5'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylate

: 1414931-43-3
3-(2'-(((2-chloro-2'-methyl-4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)amino)methyl)-3'-isopropyl-5'-(trifluoromethyl)-[1,1'-biphenyl]-4-ylcarboxamido)propanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: potassium phosphate monohydrate / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / 1,4-dioxane; water / 16 h / 90 °C

2: hydrogen / H-Cube / methanol / 40 °C / 7500.75 Torr

3: sodium hydroxide; water / tetrahydrofuran; methanol / 1 h / 60 °C

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C

5: carbon tetrabromide; triphenylphosphine / 1,2-dichloro-ethane / 16 h / 20 °C

6: potassium carbonate / acetone / 2 h / 50 °C

7: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 20 °C

With potassium phosphate monohydrate; carbon tetrabromide; water; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; sodium hydroxide; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; methanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1414931-76-2
Methyl 3'-chloro-2'-formyl-5'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylate

: 1414931-81-9
ethyl 3-(2'-(((2-chloro-2'-methyl-4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)amino)methyl)-3'-isopropyl-5'-(trifluoromethyl)-[1,1'-biphenyl]-4-ylcarboxamido)propanoate

Guidance literature:: Multi-step reaction with 6 steps

1: potassium phosphate monohydrate / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / 1,4-dioxane; water / 16 h / 90 °C

2: hydrogen / H-Cube / methanol / 40 °C / 7500.75 Torr

3: sodium hydroxide; water / tetrahydrofuran; methanol / 1 h / 60 °C

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C

5: carbon tetrabromide; triphenylphosphine / 1,2-dichloro-ethane / 16 h / 20 °C

6: potassium carbonate / acetone / 2 h / 50 °C

With potassium phosphate monohydrate; carbon tetrabromide; water; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; sodium hydroxide; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; methanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone;