2-phenyl-3-cyanonaphthoquinone

Base Information

• Chemical Name: 2-phenyl-3-cyanonaphthoquinone
• CAS No.: 101883-50-5
• Molecular Formula: C₁₇H₉NO₂
• Molecular Weight: 259.264
• Mol file: 101883-50-5.mol

Synonyms:2-phenyl-3-cyanonaphthoquinone

Chemical Property of 2-phenyl-3-cyanonaphthoquinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-phenyl-3-cyanonaphthoquinone

There total 6 articles about 2-phenyl-3-cyanonaphthoquinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

2-phenyl-acrylic acid methyl ester (1865-29-8) + 3-oxo-1,3-dihydroisobenzofuran-1-carbonitrile (27613-27-0) → 2-phenyl[1,4]naphthoquinone (2348-77-8) + 2-phenyl-3-cyanonaphthoquinone (101883-50-5)

Guidance literature:

3-oxo-1,3-dihydroisobenzofuran-1-carbonitrile; With lithium tert-butoxide; In tetrahydrofuran; at -78 - -60 ℃; for 0.416667h; Inert atmosphere;

2-phenyl-acrylic acid methyl ester; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.5b02920

Reference yield:

4-amino-1-hydroxy-3-phenyl-[2]naphthonitrile (101576-65-2) → 2-phenyl-3-cyanonaphthoquinone (101883-50-5)

Guidance literature:

With potassium dichromate;

Reference yield:

1,4-dihydroxy-3-phenyl-[2]naphthonitrile (101439-68-3) → 2-phenyl-3-cyanonaphthoquinone (101883-50-5)

Guidance literature:

With iron(III) chloride;

upstream raw materials:

4-amino-1-hydroxy-3-phenyl-[2]naphthonitrile

1,4-dihydroxy-3-phenyl-[2]naphthonitrile

phenyl benzyl ketone

(±)-1-hydroxy-3-phenyl-2-naphthonitrile