methyl N-(tert-butoxycarbonyl)-4-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-L-phenylalaninate

Base Information

Chemical Name:methyl N-(tert-butoxycarbonyl)-4-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-L-phenylalaninate
CAS No.:959992-99-5
Molecular Formula:C₂₆H₃₅N₃O₄
Molecular Weight:453.582
Hs Code.:

Synonyms:methyl N-(tert-butoxycarbonyl)-4-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-L-phenylalaninate

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Chemical Property of methyl N-(tert-butoxycarbonyl)-4-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-L-phenylalaninate

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Technology Process of methyl N-(tert-butoxycarbonyl)-4-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-L-phenylalaninate

There total 3 articles about methyl N-(tert-butoxycarbonyl)-4-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-L-phenylalaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 959992-97-3
methyl N-(tert-butoxycarbonyl)-4-[3-(1,8-naphthyridin-2-yl)prop-1-en-1-yl]-L-phenylalaninate

: 959992-99-5
methyl N-(tert-butoxycarbonyl)-4-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-L-phenylalaninate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; for 4h; under 3000.3 Torr;

Reference yield:

: 959992-96-2
2-prop-2-en-1-yl-1,8-naphthyridine

: 959992-99-5
methyl N-(tert-butoxycarbonyl)-4-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-L-phenylalaninate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / palladium diacetate; tris-(o-tolyl)phosphine / acetonitrile / 0.33 h / 150 °C / Microwave irradiation

2: hydrogen / palladium 10% on activated carbon / ethanol / 4 h / 3000.3 Torr

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium diacetate; palladium 10% on activated carbon; tris-(o-tolyl)phosphine; In ethanol; acetonitrile;

Reference yield:

: 61323-17-9
2-bromo-1,8-naphthyridine

: 959992-99-5
methyl N-(tert-butoxycarbonyl)-4-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-L-phenylalaninate

Guidance literature:: Multi-step reaction with 3 steps

1: cesium fluoride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile / 2 h / 80 °C

2: N-ethyl-N,N-diisopropylamine / palladium diacetate; tris-(o-tolyl)phosphine / acetonitrile / 0.33 h / 150 °C / Microwave irradiation

3: hydrogen / palladium 10% on activated carbon / ethanol / 4 h / 3000.3 Torr

With hydrogen; N-ethyl-N,N-diisopropylamine; cesium fluoride; palladium diacetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; tris-(o-tolyl)phosphine; In ethanol; acetonitrile; 1: Suzuki Coupling;